Inflammatory responses in hypoxic ischemic encephalopathy.

Inflammatory responses in hypoxic ischemic encephalopathy.
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DOI:
10.1038/aps.2013.89
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发表时间:
2013-09
影响因子:
8.2
通讯作者:
McCullough, Louise D.
McCullough, Louise D.
中科院分区:
医学1区
文献类型:
--
作者:
Liu, Fudong;McCullough, Louise D.

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炎症在新生儿缺氧缺血性脑病(HIE)脑损伤中起重要作用。新生儿和成人大脑对缺血的炎症反应机制可能是相同的;然而,HIE表现出独特的炎症表型,这是由于新生儿免疫系统的不成熟所致。本文就HIE急性期和亚急性期全身和局部炎症反应的研究进展作一综述。炎症的关键成分,包括免疫细胞,粘附分子,细胞因子,趋化因子和氧化应激,将被审查,新生儿和成人脑缺血损伤的炎症反应之间的差异也将被讨论。
Inflammation plays a critical role in mediating brain injury induced by neonatal hypoxic ischemic encephalopathy (HIE). The mechanisms underlying inflammatory responses to ischemia may be shared by neonatal and adult brains; however, HIE exhibits a unique inflammation phenotype that results from the immaturity of the neonatal immune system. This review will discuss the current knowledge concerning systemic and local inflammatory responses in the acute and subacute stages of HIE. The key components of inflammation, including immune cells, adhesion molecules, cytokines, chemokines and oxidative stress, will be reviewed, and the differences between neonatal and adult inflammatory responses to cerebral ischemic injury will also be discussed.
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