Conservation of the genes for HC-toxin biosynthesis in Alternaria jesenskae.
Conservation of the genes for HC-toxin biosynthesis in Alternaria jesenskae.
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DOI：
10.1186/1471-2180-13-165
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发表时间：
2013-07-17
期刊：
影响因子：
4.2
通讯作者：
Walton JD
中科院分区：
文献类型：
--
作者：
Wight WD;Labuda R;Walton JD
hc -毒素是一种环四肽，是植物病原菌碳耳蜗的毒力决定因子。最近发现，另一种真菌——赤孢霉（Alternaria jesenskae）也产生hc毒素。通过基因组测序，鉴定了叶氏拟南蝽中参与hc -毒素生物合成的主要基因（统称为AjTOX2）。所编码的同源蛋白具有75-85%的氨基酸同源性，并且hc毒素生物合成的基因在两种真菌中都是重复的。两种真菌基因的基因组组织显示出相似但不完全相同的部分聚类排列。C. carbonum和A. jesenskae具有较高的氨基酸同源性，这与C. carbonum和A. jesenskae在多孢菌科（Dothideomycetes）中亲缘关系密切一致。这是首次报道植物毒力因子hc -毒素是由碳孢菌以外的生物产生的。这些基因可能是通过水平转移在两个物种之间移动的，但不能排除它们存在于一个共同的祖先身上，而从Alternaria和Cochliobolus的其他物种身上丢失了。
HC-toxin, a cyclic tetrapeptide, is a virulence determinant for the plant pathogenic fungus Cochliobolus carbonum. It was recently discovered that another fungus, Alternaria jesenskae, also produces HC-toxin. The major genes (collectively known as AjTOX2) involved in the biosynthesis of HC-toxin were identified from A. jesenskae by genomic sequencing. The encoded orthologous proteins share 75-85% amino acid identity, and the genes for HC-toxin biosynthesis are duplicated in both fungi. The genomic organization of the genes in the two fungi show a similar but not identical partial clustering arrangement. A set of representative housekeeping proteins show a similar high level of amino acid identity between C. carbonum and A. jesenskae, which is consistent with the close relatedness of these two genera within the family Pleosporaceae (Dothideomycetes). This is the first report that the plant virulence factor HC-toxin is made by an organism other than C. carbonum. The genes may have moved by horizontal transfer between the two species, but it cannot be excluded that they were present in a common ancestor and lost from other species of Alternaria and Cochliobolus.
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影响因子：
30.8
作者：
Friesen, Timothy L.;Stukenbrock, Eva H.;Oliver, Richard P.
通讯作者：
Oliver, Richard P.
DOI：
10.1099/00221287-145-12-3539
发表时间：
1999-12-01
期刊：
MICROBIOLOGY-UK
影响因子：
--
作者：
Cheng, YQ;Ahn, JH;Walton, JD
通讯作者：
Walton, JD
影响因子：
6.7
作者：
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通讯作者：
Grigoriev IV
影响因子：
3.5
作者：
Ahn, JH;Walton, JD
通讯作者：
Walton, JD
DOI：
10.1073/pnas.231491298
发表时间：
2001-11-20
影响因子：
11.1
作者：
Pedley, KF;Walton, JD
通讯作者：
Walton, JD