An intra-individual comparison of MRI, [18F]-FET and [18F]-FLT PET in patients with high-grade gliomas.
An intra-individual comparison of MRI, [18F]-FET and [18F]-FLT PET in patients with high-grade gliomas.
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DOI：
10.1371/journal.pone.0095830
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Hutterer M
中科院分区：
文献类型：
--
作者：
Nowosielski M;DiFranco MD;Putzer D;Seiz M;Recheis W;Jacobs AH;Stockhammer G;Hutterer M
高级别胶质瘤（HGG）中MRI、氨基酸PET示踪剂[18F]-FET和核苷PET示踪剂[18F]-FLT评估的个体内肿瘤体积空间重叠分析。回顾性分析23例HGG患者的MRI、[18F]-FET和[18F]-FLT PET数据集。采用半自动图像分割方法计算MRI上肿瘤的形态体积（对比后T1 （cT1）和T2图像）。[18F]-FET和[18F]-FLT pet的代谢肿瘤体积通过基于阈值的兴趣体积分析的图像分割来确定。在与MRI共登记后，在个体基础上比较形态学和代谢肿瘤体积，以便使用Spearman等级相关系数和Mann-Whitney U检验来估计空间重叠。[18F]-FLT摄取在MRI上没有或只有中度增强的肿瘤中为阴性，23例HGG中仅检测到21例（91%）。此外，[18F]-FLT摄取主要局限于MRI上的cT1肿瘤区域，[18F]-FLT体积与cT1体积密切相关（r = 0.841, p<0.001）。相比之下，[18F]-FET PET检测到23例HGG中的22例（96%）。[18F]-FET摄取超出cT1区域的病例占61%，[18F]-FET体积与cT1体积仅呈中等相关性（r = 0.573, p<0.001）。与[18F]-FLT示踪剂摄取相比，[18F]-FET在cT1肿瘤区域外的代谢肿瘤体积明显更大（8.3 cm3 vs. 2.7 cm3, p<0.001）。在HGG中[18F]-FET而不是[18F]-FLT PET能够检测到代谢活跃的肿瘤组织，而不是MRI上的对比增强肿瘤。与[18F]-FET相反，血脑屏障的破坏似乎是[18F]-FLT示踪剂摄取的先决条件。
Intra-individual spatial overlap analysis of tumor volumes assessed by MRI, the amino acid PET tracer [18F]-FET and the nucleoside PET tracer [18F]-FLT in high-grade gliomas (HGG). MRI, [18F]-FET and [18F]-FLT PET data sets were retrospectively analyzed in 23 HGG patients. Morphologic tumor volumes on MRI (post-contrast T1 (cT1) and T2 images) were calculated using a semi-automatic image segmentation method. Metabolic tumor volumes for [18F]-FET and [18F]-FLT PETs were determined by image segmentation using a threshold-based volume of interest analysis. After co-registration with MRI the morphologic and metabolic tumor volumes were compared on an intra-individual basis in order to estimate spatial overlaps using the Spearman's rank correlation coefficient and the Mann-Whitney U test. [18F]-FLT uptake was negative in tumors with no or only moderate contrast enhancement on MRI, detecting only 21 of 23 (91%) HGG. In addition, [18F]-FLT uptake was mainly restricted to cT1 tumor areas on MRI and [18F]-FLT volumes strongly correlated with cT1 volumes (r = 0.841, p<0.001). In contrast, [18F]-FET PET detected 22 of 23 (96%) HGG. [18F]-FET uptake beyond areas of cT1 was found in 61% of cases and [18F]-FET volumes showed only a moderate correlation with cT1 volumes (r = 0.573, p<0.001). Metabolic tumor volumes beyond cT1 tumor areas were significantly larger for [18F]-FET compared to [18F]-FLT tracer uptake (8.3 vs. 2.7 cm3, p<0.001). In HGG [18F]-FET but not [18F]-FLT PET was able to detect metabolic active tumor tissue beyond contrast enhancing tumor on MRI. In contrast to [18F]-FET, blood-brain barrier breakdown seems to be a prerequisite for [18F]-FLT tracer uptake.
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影响因子：
4.1
作者：
Floeth, FW;Pauleit, D;Sabel, M
通讯作者：
Sabel, M
影响因子：
45.3
作者：
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影响因子：
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作者：
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DOI：
10.1007/s00259-005-0002-5
发表时间：
2006-05-01
影响因子：
9.1
作者：
Galldiks, N;Kracht, LW;Herholz, K
通讯作者：
Herholz, K
影响因子：
2.5
作者：
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