Computed tomography and magnetic resonance imaging evaluation of pelvic lymph node metastasis in bladder cancer.
Computed tomography and magnetic resonance imaging evaluation of pelvic lymph node metastasis in bladder cancer.
复制标题
膀胱癌盆腔淋巴结转移的CT和磁共振成像评估
DOI：
10.1186/s40880-018-0269-0
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发表时间：
2018-01-26
影响因子：
--
通讯作者：
Lin T
中科院分区：
文献类型：
--
作者：
Li Y;Diao F;Shi S;Li K;Zhu W;Wu S;Lin T
BackgroundAccurate evaluation of lymph node metastasis in bladder cancer (BCa) is important for disease staging, treatment selection, and prognosis prediction. In this study, we aimed to evaluate the diagnostic accuracy of computed tomography (CT) and magnetic resonance imaging (MRI) for metastatic lymph nodes in BCa and establish criteria of imaging diagnosis.MethodsWe retrospectively assessed the imaging characteristics of 191 BCa patients who underwent radical cystectomy. The data regarding size, shape, density, and diffusion of the lymph nodes on CT and/or MRI were obtained and analyzed using Kruskal–Wallis test and χ2test. The optimal cutoff value for the size of metastatic node was determined using the receiver operating characteristic (ROC) curve analysis.ResultsA total of 184 out of 3317 resected lymph nodes were diagnosed as metastatic lymph nodes. Among 82 imaging-detectable lymph nodes, 51 were confirmed to be positive for metastasis. The detection rate of metastatic nodes increased along with more advanced tumor stage (P< 0.001). Once the ratio of short- to long-axis diameter ≤ 0.4 or fatty hilum was observed in lymph nodes on imaging, it indicated non-metastases. Besides, lymph nodes with spiculate or obscure margin or necrosis indicated metastases. Furthermore, the short diameter of 6.8 mm was the optimal threshold to diagnose metastatic lymph node, with the area under ROC curve of 0.815.ConclusionsThe probability of metastatic nodes significantly increased with more advanced T stages. Once lymph nodes are detected on imaging, the characteristic signs should be paid attention to. The short diameter > 6.8 mm may indicate metastatic lymph nodes in BCa.
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影响因子：
19.7
作者：
Thoeny, Harriet C.;Froehlich, Johannes M.;Studer, Urs E.
通讯作者：
Studer, Urs E.
影响因子：
1.3
作者：
Nakai, Go;Matsuki, Mitsuru;Yamada, Takashi
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Yamada, Takashi
影响因子：
158.5
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Harisinghani, MG;Barentsz, J;Weissleder, R
通讯作者：
Weissleder, R
影响因子：
19.7
作者：
Yang, WT;Chang, J;Metreweli, C
通讯作者：
Metreweli, C
影响因子：
2.1
作者：
Saokar, Anuradha;Islam, Tina;Harisinghani, Mukesh G.
通讯作者：
Harisinghani, Mukesh G.