The Association between Peptic Ulcer Disease and Gastric Cancer: Results from the Stomach Cancer Pooling (StoP) Project Consortium.
The Association between Peptic Ulcer Disease and Gastric Cancer: Results from the Stomach Cancer Pooling (StoP) Project Consortium.
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胃癌(GC)是第五种最常见的癌症类型，也是与癌症相关的死亡的第四大常见原因。在这项荟萃分析中，我们利用STOP联盟的数据来研究胃溃疡(GU)和十二指肠溃疡(DU)与GC发生之间的关系。在4106例胃癌患者和6922例对照中，GU与GC呈正相关(OR=3.04，95%CI：2.07~4.49)。DU与GC无明显相关性(OR=1.03，95%CI：0.77~1.39)。在综合分析中，11项病例对照研究显示胃溃疡与患胃癌的风险呈正相关。背景资料。胃癌(GC)是第五种最常见的癌症类型，也是与癌症相关的死亡的第四大常见原因。虽然幽门螺杆菌感染会增加胃癌和消化性溃疡疾病(PUD)的风险，但关于不同种族的PUD和GC之间的直接关系的证据尚不确定。因此，我们调查了胃癌联合(STOP)联盟中PUD和GC之间的关系。方法：研究方法。在STOP联盟的11项研究中，使用结构化问卷收集了消化性溃疡病史，其中包括4106例GC病例和6922名对照。采用两阶段个体-参与者数据荟萃分析方法生成先验。采用非条件Logistic回归和Firth惩罚最大似然估计法计算胃溃疡(GU)/十二指肠溃疡(DU)与胃癌风险之间的研究特异性优势比(OR)和95%可信区间(CI)。结果。分别有487例(12.5%)和276例对照(4.1%)和253例(7.8%)和318例(6.0%)对照报告了GU和DU病史并进行关联分析。我们发现GU与胃癌的风险增加有关(OR=3.04，95%CI：2.07-4.49)。未观察到DU与GC风险相关(OR=1.03，95%CI：0.77~1.39)。结论。在对一个大型联盟(即胃癌联合(STOP)联盟)的11项病例对照研究进行的综合分析中，我们发现GU与胃癌风险呈正相关，而DU与GC风险无关联。
Gastric cancer (GC) is the fifth most common type of cancer and the fourth most common cause of cancer-related mortality. In this meta-analysis, we utilized SToP consortium data to investigate the association between gastric ulcer (GU) and duodenal ulcer (DU) and development of GC. Among 4106 GC cases and 6922 controls, we detected a positive association between GU and GC (OR = 3.04, 95% CI: 2.07–4.49). On the other hand, no significant association between DU and GC was detected (OR = 1.03, 95% CI: 0.77–1.39). In the pooled analysis, incorporating 11 case–control studies revealed positive association between the gastric ulcer and risk of gastric cancer. Background. Gastric cancer (GC) is the fifth most common type of cancer and the fourth most common cause of cancer-related mortality. Although the risk of GC and peptic ulcer disease (PUD) is known to be increased by H. pylori infection, evidence regarding the direct relationship between PUD and GC across ethnicities is inconclusive. Therefore, we investigated the association between PUD and GC in the Stomach cancer Pooling (StoP) consortium. Methods. History of peptic ulcer disease was collected using a structured questionnaire in 11 studies in the StoP consortium, including 4106 GC cases and 6922 controls. The two-stage individual-participant data meta-analysis approach was adopted to generate a priori. Unconditional logistic regression and Firth’s penalized maximum likelihood estimator were used to calculate study-specific odds ratios (ORs) and 95% confidence intervals (CIs) for the association between gastric ulcer (GU)/duodenal ulcer (DU) and risk of GC. Results. History of GU and DU was thoroughly reported and used in association analysis, respectively, by 487 cases (12.5%) and 276 controls (4.1%), and 253 cases (7.8%) and 318 controls (6.0%). We found that GU was associated with an increased risk of GC (OR = 3.04, 95% CI: 2.07–4.49). No association between DU and GC risk was observed (OR = 1.03, 95% CI: 0.77–1.39). Conclusions. In the pooled analysis of 11 case–control studies in a large consortium (i.e., the Stomach cancer Pooling (StoP) consortium), we found a positive association between GU and risk of GC and no association between DU and GC risk.
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韩国的癌症统计：2008年的发病率，死亡率，生存和患病率。
影响因子：
4.6
作者：
Jung KW;Park S;Kong HJ;Won YJ;Lee JY;Park EC;Lee JS
通讯作者：
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影响因子：
4.3
作者：
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通讯作者：
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DOI：
10.1007/s10120-004-0268-5
发表时间：
2004-01-01
期刊：
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
影响因子：
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作者：
Machida-Montani, Ai;Sasazuki, Shizuka;Tsugane, Shoichiro
通讯作者：
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影响因子：
2.7
作者：
FIRTH, D
通讯作者：
FIRTH, D
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
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作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N