Effects of sleep deprivation on neural functioning: an integrative review.
Effects of sleep deprivation on neural functioning: an integrative review.
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DOI：
10.1007/s00018-007-6457-8
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发表时间：
2007-04
影响因子：
8
通讯作者：
Beek, P. J.
中科院分区：
文献类型：
--
作者：
Boonstra, T. W.;Stins, J. F.;Daffertshofer, A.;Beek, P. J.
睡眠剥夺对人类的表现和神经功能有各种各样的影响，表现在不同的描述水平上。在宏观层面上，睡眠剥夺主要影响执行功能，特别是在新任务中。睡眠剥夺对大脑活动的宏观和中观影响包括皮质对传入刺激的反应性降低，反映了注意力降低。在微观层面上，睡眠剥夺与腺苷水平的增加有关，腺苷是一种对神经活动具有一般抑制作用的神经调节剂。胆碱能核的抑制似乎特别相关，因为皮层乙酰胆碱的相关减少似乎会导致睡眠剥夺对宏观大脑活动的影响。然而，一般来说，睡眠剥夺的神经效应之间的关系在观察尺度上知之甚少，揭示这些关系应该是未来研究的主要目标。
Sleep deprivation has a broad variety of effects on human performance and neural functioning that manifest themselves at different levels of description. On a macroscopic level, sleep deprivation mainly affects executive functions, especially in novel tasks. Macroscopic and mesoscopic effects of sleep deprivation on brain activity include reduced cortical responsiveness to incoming stimuli, reflecting reduced attention. On a microscopic level, sleep deprivation is associated with increased levels of adenosine, a neuromodulator that has a general inhibitory effect on neural activity. The inhibition of cholinergic nuclei appears particularly relevant, as the associated decrease in cortical acetylcholine seems to cause effects of sleep deprivation on macroscopic brain activity. In general, however, the relationships between the neural effects of sleep deprivation across observation scales are poorly understood and uncovering these relationships should be a primary target in future research.
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DOI：
10.1152/ajpregu.1999.277.6.r1771
发表时间：
1999-12-01
影响因子：
2.8
作者：
Aeschbach, D;Matthews, JR;Wehr, TA
通讯作者：
Wehr, TA
影响因子：
2.9
作者：
Boonstra, T. W.;Daffertshofer, A.;Beek, Pj.
通讯作者：
Beek, Pj.
影响因子：
3.8
作者：
ACHERMANN, P;DIJK, DJ;BORBELY, AA
通讯作者：
BORBELY, AA
影响因子：
3.3
作者：
Arrigoni, E.;Chamberlin, N. L.;McCarley, R. W.
通讯作者：
McCarley, R. W.
影响因子：
2.5
作者：
Boonstra, TW;Daffertshofer, A;Beek, PJ
通讯作者：
Beek, PJ