A global view of comorbidity in multiple sclerosis: a systematic review with a focus on regional differences, methodology, and clinical implications.
A global view of comorbidity in multiple sclerosis: a systematic review with a focus on regional differences, methodology, and clinical implications.
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DOI：
10.1007/s00415-020-10107-y
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发表时间：
2021-11
影响因子：
6
通讯作者：
Sellner J
中科院分区：
文献类型：
--
作者：
Hauer L;Perneczky J;Sellner J
多发性硬化症（MS）是一种中枢神经系统的慢性自身免疫性疾病，与许多合并症有关。这些疾病包括心血管疾病、精神和神经紊乱、不宁腿综合征、偏头痛、癌症、自身免疫性疾病和代谢紊乱。合并症是临床医生治疗MS患者的重要考虑因素;合并症的早期表现可能使MS诊断模糊或延迟，并显著影响病程。提高对MS人群中合并症及其出现的理解对于改善患者的生活质量和优化治疗非常重要。因此，我们评估了已发表的研究，这些研究报告了MS患者（PwMS）合并症及其对疾病进展的相关影响的流行病学数据。神经系统、心血管、代谢和自身免疫性合并症的患病率在PwMS中普遍升高，此外，这对广泛的结局产生了不利影响。与PwMS相比，没有MS的人或普通人群的癌症发病率较低，这应该促使对这两种疾病的机制进行进一步研究。在许多地区，由于地中海的纬度梯度和研究经费可能不足，研究的代表性不足。本文的在线版本（10.1007/s 00415 -020-10107-y）包含补充材料，可供授权用户使用。
Multiple sclerosis (MS) is a chronic autoimmune disorder of the central nervous system which is associated with numerous comorbidities. These include cardiovascular disease, psychiatric and neurologic disturbances, restless leg syndrome, migraine, cancer, autoimmune diseases, and metabolic disorders. Comorbid disease is an important consideration for clinicians treating patients with MS; early presentation of comorbidities can obscure or delay MS diagnosis, as well as significantly impacting the disease course. Improved understanding of comorbidities and their emergence in MS populations is important for improving the quality of life and optimizing treatment for patients. Therefore, we evaluated published studies reporting epidemiologic data on comorbidities and their associated impact on disease progression in patients with MS (PwMS). The prevalence of neurologic, cardiovascular, metabolic, and autoimmune comorbidities was elevated in PwMS in general, and furthermore, this adversely affected a broad range of outcomes. Compared with PwMS, cancer rates in people without MS or the general population were lower, which should prompt further studies into the mechanisms of both diseases. Studies were under-represented in many regions owing to the latitudinal gradient of MS and possible underfunding of studies. The online version of this article (10.1007/s00415-020-10107-y) contains supplementary material, which is available to authorized users.
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影响因子：
2.5
作者：
Alsaadi T;El Hammasi K;Shahrour TM;Shakra M;Turkawi L;Mudhafar A;Diab L;Raoof M
通讯作者：
Raoof M
DOI：
10.1016/s1474-4422(17)30299-5
发表时间：
2017-11
期刊：
The Lancet. Neurology
影响因子：
--
作者：
GBD 2015 Neurological Disorders Collaborator Group
通讯作者：
GBD 2015 Neurological Disorders Collaborator Group
影响因子：
3.3
作者：
Burns MN;Nawacki E;Siddique J;Pelletier D;Mohr DC
通讯作者：
Mohr DC
影响因子：
5.1
作者：
Chou, I. J.;Kuo, C. F.;Whitehouse, W. P.
通讯作者：
Whitehouse, W. P.
影响因子：
7.3
作者：
de Cerqueira, Ana Claudia;de Andrade, Patricia Semionato;Nardi, Antonio Egidio
通讯作者：
Nardi, Antonio Egidio