Diverse Physiological Roles of Calcitonin Gene-Related Peptide in Migraine Pathology: Modulation of Neuronal-Glial-Immune Cells to Promote Peripheral and Central Sensitization.
Diverse Physiological Roles of Calcitonin Gene-Related Peptide in Migraine Pathology: Modulation of Neuronal-Glial-Immune Cells to Promote Peripheral and Central Sensitization.
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DOI：
10.1007/s11916-016-0578-4
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发表时间：
2016-08
影响因子：
3.7
通讯作者：
Durham PL
中科院分区：
文献类型：
--
作者：
Durham PL
神经肽降钙素基因相关肽(CGRP)通过促进初级和次级伤害性感受性神经元的敏化状态的发展而参与偏头痛的潜在病理。CGRP启动和维持外周和中枢敏化的能力是通过调节三叉神经伤害性信号通路中的神经元、神经胶质细胞和免疫细胞来实现的。越来越多的证据支持CGRP在促进三叉神经节内交叉兴奋中的关键作用，这可能有助于解释偏头痛与鼻窦炎和颞下颌关节紊乱病高发病率的原因。此外，有新的证据表明，CGRP促进和维持偏头痛患者由压力和焦虑等危险因素介导的高反应性神经元状态。在这篇综述中，将讨论CGRP作为三叉神经系统调节器的重要作用，以更好地了解与偏头痛表型相关的潜在病理。
The neuropeptide calcitonin gene-related peptide (CGRP) is implicated in the underlying pathology of migraine by promoting the development of a sensitized state of primary and secondary nociceptive neurons. The ability of CGRP to initiate and maintain peripheral and central sensitization is mediated by modulation of neuronal, glial, and immune cells in the trigeminal nociceptive signaling pathway. There is accumulating evidence to support a key role of CGRP in promoting cross excitation within the trigeminal ganglion that may help to explain the high co-morbidity of migraine with rhinosinusitis and temporomandibular joint disorder. In addition, there is emerging evidence that CGRP facilitates and sustains a hyperresponsive neuronal state in migraineurs mediated by reported risk factors such as stress and anxiety. In this review, the significant role of CGRP as a modulator of the trigeminal system will be discussed to provide a better understanding of the underlying pathology associated with the migraine phenotype.
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