Blend sign predicts poor outcome in patients with intracerebral hemorrhage.
Blend sign predicts poor outcome in patients with intracerebral hemorrhage.
复制标题
混合符号预测脑出血患者的预后不良。
DOI：
10.1371/journal.pone.0183082
复制
发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Xie P
中科院分区：
文献类型：
--
作者：
Li Q;Yang WS;Wang XC;Cao D;Zhu D;Lv FJ;Liu Y;Yuan L;Zhang G;Xiong X;Li R;Hu YX;Qin XY;Xie P
混合征最近被描述为一种新的预测血肿扩大的影像学标记。本研究旨在探讨CT混合征对脑出血患者预后的价值。纳入了在6小时内接受基线CT扫描的脑出血患者。由两名阅片者独立评估入院时平扫CT上混合征的存在。术后90天采用改良兰金量表（mRS）评定功能结局。238例患者入院时CT扫描发现混合征40例（16.8%）。有混合征的患者中功能结局较差的患者比例明显高于无混合征的患者（75.0%比47.5%，P = 0.001）。多因素Logistic回归分析显示，年龄、脑室内出血、入院GCS评分、基线血肿体积和基线CT上混合征的存在独立预测90天时的不良功能结局。CT混合征独立预测ICH患者的不良结局（比值比3.61，95%置信区间[1.47-8.89];p = 0.005）。混合征的早期识别有助于预后分层，并可作为前瞻性干预研究的潜在治疗靶点。
Blend sign has been recently described as a novel imaging marker that predicts hematoma expansion. The purpose of our study was to investigate the prognostic value of CT blend sign in patients with ICH. Patients with intracerebral hemorrhage who underwent baseline CT scan within 6 hours were included. The presence of blend sign on admission nonenhanced CT was independently assessed by two readers. The functional outcome was assessed by using the modified Rankin Scale (mRS) at 90 days. Blend sign was identified in 40 of 238 (16.8%) patients on admission CT scan. The proportion of patients with a poor functional outcome was significantly higher in patients with blend sign than those without blend sign (75.0% versus 47.5%, P = 0.001). The multivariate logistic regression analysis demonstrated that age, intraventricular hemorrhage, admission GCS score, baseline hematoma volume and presence of blend sign on baseline CT independently predict poor functional outcome at 90 days. The CT blend sign independently predicts poor outcome in patients with ICH (odds ratio 3.61, 95% confidence interval [1.47–8.89];p = 0.005). Early identification of blend sign is useful in prognostic stratification and may serve as a potential therapeutic target for prospective interventional studies.
登录
查看更多内容
影响因子：
8.2
作者：
An SJ;Kim TJ;Yoon BW
通讯作者：
Yoon BW
DOI：
10.1159/000346599
发表时间：
2013
期刊：
Cerebrovascular diseases (Basel, Switzerland)
影响因子：
--
作者：
Brouwers HB;Greenberg SM
通讯作者：
Greenberg SM
影响因子：
48
作者：
van Asch, Charlotte J. J.;Luitse, Merel J. A.;Klijn, Catharina J. M.
通讯作者：
Klijn, Catharina J. M.
影响因子：
8.3
作者：
Brouwers, H. Bart;Battey, Thomas W. K.;Romero, Javier M.
通讯作者：
Romero, Javier M.
影响因子：
9.9
作者：
Goldstein, J. N.;Fazen, L. E.;Rosand, J.
通讯作者：
Rosand, J.