Long-term, infection-acquired immunity against the SARS-CoV-2 Delta variant in a hamster model.
Long-term, infection-acquired immunity against the SARS-CoV-2 Delta variant in a hamster model.
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DOI：
10.1016/j.celrep.2022.110394
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发表时间：
2022-02-15
期刊：
影响因子：
8.8
通讯作者：
Kawaoka Y
中科院分区：
文献类型：
--
作者：
Halfmann PJ;Kuroda M;Armbrust T;Accola M;Valdez R;Kowalski-Dobson T;Rehrauer W;Gordon A;Kawaoka Y
SARS-CoV-2 Delta变体（B.1.617.2）的出现引发了人们对病毒对抗体中和和随后的疫苗突破感染的敏感性可能降低的担忧。在这里，我们对辉瑞和moderna疫苗接种个体的血清使用活病毒中和试验来检测针对SARS-CoV-2的中和抗体滴度，并观察到与早期仅在刺突蛋白中含有D614G替代的分离物相比，针对Delta变体的中和抗体滴度分别降低了3.9倍和2.7倍。我们观察到，先前感染过SARS-CoV-2早期分离株的仓鼠血清的敏感性也出现了类似的降低。尽管针对Delta变体的中和抗体滴度降低，但先前感染（最多15个月前）早期分离物的仓鼠免受Delta变体感染，这表明对第一次感染的免疫反应足以提供抵抗后续Delta变体感染的保护。随着SARS-CoV-2变异体积累突变，存在针对新变异体的无效中和抗体和潜在的再次感染的风险。Halfmann等人报道，在仓鼠模型中，先前感染过早期原型SARS-CoV-2分离物可防止Delta变体的再次感染及其传播给幼稚仓鼠。
The emergence of the SARS-CoV-2 Delta variant (B.1.617.2) raises concerns about potential reduced sensitivity of the virus to antibody neutralization and subsequent vaccine breakthrough infections. Here, we use a live virus neutralization assay with sera from Pfizer- and Moderna-vaccinated individuals to examine neutralizing antibody titers against SARS-CoV-2 and observe a 3.9- and 2.7-fold reduction, respectively, in neutralizing antibody titers against the Delta variant compared with an early isolate bearing only a D614G substitution in its spike protein. We observe similar reduced sensitivity with sera from hamsters that were previously infected with an early isolate of SARS-CoV-2. Despite this reduction in neutralizing antibody titers against the Delta variant, hamsters previously infected (up to 15 months earlier) with an early isolate are protected from infection with the Delta variant, suggesting that the immune response to the first infection is sufficient to provide protection against subsequent infection with the Delta variant. As SARS-CoV-2 variants accumulate mutations, there is a risk of ineffective neutralizing antibodies against new variants and potential re-infection. Halfmann et al. report that, in the hamster model, previous infection with an early prototypical SARS-CoV-2 isolate prevents re-infection of the Delta variant and its transmission to naive hamsters.
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影响因子：
16.6
作者：
Li B;Deng A;Li K;Hu Y;Li Z;Shi Y;Xiong Q;Liu Z;Guo Q;Zou L;Zhang H;Zhang M;Ouyang F;Su J;Su W;Xu J;Lin H;Sun J;Peng J;Jiang H;Zhou P;Hu T;Luo M;Zhang Y;Zheng H;Xiao J;Liu T;Tan M;Che R;Zeng H;Zheng Z;Huang Y;Yu J;Yi L;Wu J;Chen J;Zhong H;Deng X;Kang M;Pybus OG;Hall M;Lythgoe KA;Li Y;Yuan J;He J;Lu J
通讯作者：
Lu J
DOI：
10.1126/science.abe8499
发表时间：
2020-12-18
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Hou YJ;Chiba S;Halfmann P;Ehre C;Kuroda M;Dinnon KH 3rd;Leist SR;Schäfer A;Nakajima N;Takahashi K;Lee RE;Mascenik TM;Graham R;Edwards CE;Tse LV;Okuda K;Markmann AJ;Bartelt L;de Silva A;Margolis DM;Boucher RC;Randell SH;Suzuki T;Gralinski LE;Kawaoka Y;Baric RS
通讯作者：
Baric RS
影响因子：
64.8
作者：
Imai, Masaki;Watanabe, Tokiko;Hatta, Masato;Das, Subash C.;Ozawa, Makoto;Shinya, Kyoko;Zhong, Gongxun;Hanson, Anthony;Katsura, Hiroaki;Watanabe, Shinji;Li, Chengjun;Kawakami, Eiryo;Yamada, Shinya;Kiso, Maki;Suzuki, Yasuo;Maher, Eileen A.;Neumann, Gabriele;Kawaoka, Yoshihiro
通讯作者：
Kawaoka, Yoshihiro
影响因子：
64.8
作者：
Planas, Delphine;Veyer, David;Schwartz, Olivier
通讯作者：
Schwartz, Olivier
与祖先的SARS-COV-2病毒相比，SARS-COV-2的三角洲变体的生殖数量要高得多。
影响因子：
25.7
作者：
Liu Y;Rocklöv J
通讯作者：
Rocklöv J