HCMV IL-10 suppresses cytokine expression in monocytes through inhibition of nuclear factor-kappaB.
HCMV IL-10 suppresses cytokine expression in monocytes through inhibition of nuclear factor-kappaB.
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DOI：
10.1089/vim.2008.0048
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发表时间：
2008-12
期刊：
影响因子：
2.2
通讯作者：
Spencer JV
中科院分区：
文献类型：
--
作者：
Nachtwey J;Spencer JV
Modulation of host immune responses is a common strategy for promoting virus persistence and avoiding clearance. Human cytomegalovirus (HCMV) is known to encode numerous immunomodulatory genes, including a homolog of the human cytokine interleukin-10 (hIL-10). While having limited sequence homology to hIL-10, cmvIL-10 shares many functional characteristics with the human cytokine and acts as a potent suppressor of the inflammatory immune response. The mechanism by which hIL-10 inhibits inflammatory cytokines involves a transcriptional block via inhibition of NF-κB activity. To determine whether cmvIL-10 employs the same mechanism to inhibit cytokine production, the effect of cmvIL-10 on NF-κB signaling in monocytes was investigated. The results demonstrate that cmvIL-10 does inhibit NF-κB activation, as evidenced by reduced degradation of the NF-κB inhibitor IκB-α and decreased transcription of the NF-κB responsive genes TNF-α and IL-1β. These studies confirm that cmvIL-10 mediates cytokine suppression by blocking NF-κB transcriptional activity in human monocytes.
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影响因子：
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