Actin network architecture can determine myosin motor activity.
Actin network architecture can determine myosin motor activity.
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DOI：
10.1126/science.1221708
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发表时间：
2012-06-08
期刊：
影响因子：
--
通讯作者：
Blanchoin L
中科院分区：
文献类型：
--
作者：
Reymann AC;Boujemaa-Paterski R;Martiel JL;Guérin C;Cao W;Chin HF;De La Cruz EM;Théry M;Blanchoin L
The organization of actin filaments into higher-ordered structures governs eukaryotic cell shape and movement. Global actin network size and architecture is maintained in a dynamic steady-state through regulated assembly and disassembly. Here, we used experimentally defined actin structures in vitro to investigate how the activity of myosin motors depends on network architecture. Direct visualization of filaments revealed myosin-induced actin network deformation. During this reorganization myosins selectively contracted and disassembled anti-parallel actin structures while parallel actin bundles remained unaffected. The local distribution of nucleation sites and the resulting orientation of actin filaments appeared to regulate the scalability of the contraction process. This “orientation selection” mechanism for selective contraction and disassembly suggests how the dynamics of the cellular actin cytoskeleton can be spatially controlled by actomyosin contractility.
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影响因子：
5.6
作者：
Haviv, Lior;Gillo, David;Bernheim-Groswasser, Anne
通讯作者：
Bernheim-Groswasser, Anne
影响因子：
4.8
作者：
De la Cruz, EM;Ostap, EM;Sweeney, HL
通讯作者：
Sweeney, HL
影响因子：
64.5
作者：
Carvalho, Ana;Desai, Arshad;Oegema, Karen
通讯作者：
Oegema, Karen
DOI：
10.1083/jcb.131.1.179
发表时间：
1995-10
期刊：
The Journal of cell biology
影响因子：
--
作者：
Cramer LP;Mitchison TJ
通讯作者：
Mitchison TJ
影响因子：
64.8
作者：
通讯作者：
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