The role of macrophage phenotype in regulating the response to radiation therapy.
The role of macrophage phenotype in regulating the response to radiation therapy.
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DOI：
10.1016/j.trsl.2017.11.002
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发表时间：
2018-01
期刊：
影响因子：
--
通讯作者：
Shiao SL
中科院分区：
文献类型：
--
作者：
Shi X;Shiao SL
Increasing experimental and clinical evidence has revealed a critical role for myeloid cells in the development and progression of cancer. The ability of monocytes and macrophages to regulate inflammation allows them to manipulate the tumor microenvironment to support the growth and development of malignant cells. Recent studies have shown that macrophages can exist in several functional states depending on the microenvironment they encounter in the tissue. These functional phenotypes not only influence the genesis and propagation of tumors, but also the efficacy of cancer therapies particularly radiation. Early classification of the macrophage phenotypes, or “polarization states”, identified two major states, M1 and M2, that have cytotoxic and wound repair capacity respectively. In the context of tumors, classically activated or M1 macrophages driven by IFN-gamma support anti-tumor immunity while alternatively activated or M2 macrophages generated in part from interleukin-4 exposure hinder anti-tumor immunity by suppressing cytotoxic responses against a tumor. In this review, we discuss the role that the functional phenotype of a macrophage population plays in tumor development. We will then focus more specifically on how macrophages and myeloid cells regulate the tumor response to radiation therapy.
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