Cholinergic modulation of frequency receptive fields in auditory cortex: I. Frequency‐specific effects of muscarinic agonists
Cholinergic modulation of frequency receptive fields in auditory cortex: I. Frequency‐specific effects of muscarinic agonists
复制标题
听觉皮层频率感受野的胆碱能调节：I. 毒蕈碱激动剂的频率特异性效应
作者：
T. McKenna;J. Ashe;N. Weinberger
以前我们报道乙酰胆碱（ACh）和乙酰-β-乙酰甲胆碱（MCh）改变听觉皮层神经元对单个频率的反应。本研究的目的是确定毒蕈碱激动剂是否产生细胞反应的频率特异性改变或一般变化。频率特异性修改在频率感受野（FRF）的改变中是明显的，这些频率感受野在不同频率之间是不同的，而一般效应将被视为在频率上或多或少相同的变化。单神经元的反应，以指定的一组音调记录在听觉皮层的长期准备清醒猫之前，期间，和之后的喷射乙酰胆碱或MCH的离子电渗或微压使用多管微量移液管。频率感受野的确定，提出等强度的音调在一系列的频率，包括细胞的最佳频率（BF）的音调开始。还定量测定了“关闭”和“持续（通过）”反应的FRF。ACh和MCh的影响主要是频率特异性的（77%，39/51个细胞）;一般变化（19%，10/51）和无影响（4%，2/51）的可能性较小。频率特异性效应涉及同一神经元内对不同频率的相同响应分量的促进和减少。对于对音调起始的反应（但不是“通过”和“关闭”反应），激动剂更可能在BF处产生降低，同时增加对其他频率的反应。激动剂可以增加或减少频率选择性。激动剂的作用可被阿托品阻断，表明与毒蕈碱受体有关。
Previously we reported that acetylcholine (ACh) and acetyl‐beta‐methacholine (MCh) modify responses of neurons in auditory cortex to individual frequencies. The purpose of this study was to determine whether muscarinic agonists produce frequency‐specific alterations or general changes in cellular responses. Frequency‐specific modifications would be evident in alterations of frequency receptive fields (FRF) that differed across frequencies while general effects would be seen as changes that were more or less the same over frequencies. Responses of single neurons to designated sets of tones were recorded in the auditory cortex of chronically prepared awake cats before, during, and following ejection of ACh or MCh by iontophoresis or micropressure using multibarrel micropipettes. Frequency receptive fields were determined by presenting isointensity tones across a range of frequencies including the cell's best frequency (BF) to tone onset. FRF for “off” and “sustained (through)” responses were also determined quantitatively. The effects of ACh and MCh were predominantly frequency‐specific (77%, 39/51 cells); general changes (19%, 10/51) and no effects (4%, 2/51) were less likely. Frequency‐specific effects involved both facilitation and reduction of the same response component to different frequencies within the same neuron. For responses to tone onset (but not “through” and “off” responses), agonists were more likely to produce a decrease at the BF while simultaneously increasing responses to other frequencies. Agonists could increase or decrease frequency selectivity. Effects of agonists could be blocked by atropine, suggesting involvement of muscarinic receptors.
乙酰胆碱对猫体感皮层神经元反应特性的影响。
影响因子：
2.5
作者：
Metherate,R;Tremblay,N;Dykes,RW
通讯作者：
Dykes,RW
未麻醉猫背侧和后腹侧耳蜗核神经元的生理研究。
影响因子：
2.5
作者：
Rhode,WS;Kettner,RE
通讯作者：
Kettner,RE
乙酰胆碱对猫体感皮层神经元反应性的短暂和长期影响。
影响因子：
2.5
作者：
Metherate,R;Tremblay,N;Dykes,RW
通讯作者：
Dykes,RW