Function, molecular mechanisms, and therapeutic potential of bacterial HtrA proteins: An evolving view.
Function, molecular mechanisms, and therapeutic potential of bacterial HtrA proteins: An evolving view.
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细菌 HtrA 蛋白的功能、分子机制和治疗潜力：不断发展的观点
DOI：
10.1016/j.csbj.2021.12.004
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发表时间：
2022
影响因子：
6
通讯作者：
Bao R
中科院分区：
文献类型：
--
作者：
Song Y;Ke Y;Kang M;Bao R
高温需要A（HtrA）蛋白家族的成员广泛分布于原核和真核生物物种中。HtrA蛋白具有ATP非依赖性的双重伴侣蛋白酶活性，并介导蛋白质质量控制。新出现的证据表明，HtrA家族成员对于在压力条件下建立感染和细菌存活至关重要。细菌HtrA蛋白越来越被认为是抗菌药物开发的重要新靶点，最近的文献表明铜绿假单胞菌HtrA蛋白AlgW具有独特的结构、功能和调控特性。在AlgW中看到的新的双信号激活机制是调节细菌中的应激和药物反应所必需的，这促使我们回顾我们对微生物中发现的许多HtrA蛋白的理解。在这里，我们描述了HtrA基因的直系同源物在病原菌中的分布，讨论了它们的结构与功能的关系，概述了不同的细菌HtrA蛋白在细菌中的选择压力下所表现出的分子机制，并回顾了最近开发的针对HtrA的小分子抑制剂在病原菌中的意义。
Members of the high temperature requirement A (HtrA) protein family are widely distributed amongst prokaryotic and eukaryotic species. HtrA proteins have ATP-independent dual chaperone-protease activity and mediate protein quality control. Emerging evidence indicates that HtrA family members are vital for establishing infections and bacterial survival under stress conditions. Bacterial HtrA proteins are increasingly thought of as important new targets for antibacterial drug development. Recent literature suggests that HtrA protein AlgW from Pseudomonas aeruginosa has distinct structural, functional, and regulatory characteristics. The novel dual-signal activation mechanism seen in AlgW is required to modulate stress and drug responses in bacteria, prompting us to review our understanding of the many HtrA proteins found in microorganisms. Here, we describe the distribution of HtrA gene orthologues in pathogenic bacteria, discuss their structure–function relationships, outline the molecular mechanisms exhibited by different bacterial HtrA proteins in bacteria under selective pressure, and review the significance of recently developed small molecule inhibitors targeting HtrA in pathogenic bacteria.
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影响因子：
4.6
作者：
Chao Y;Bergenfelz C;Sun R;Han X;Achour A;Hakansson AP
通讯作者：
Hakansson AP
影响因子：
5.6
作者：
de Dios R;Santero E;Reyes-Ramírez F
通讯作者：
Reyes-Ramírez F
影响因子：
7.7
作者：
Hoy, Benjamin;Loewer, Martin;Wessler, Silja
通讯作者：
Wessler, Silja
DOI：
10.1186/s12964-016-0153-y
发表时间：
2016-12-08
期刊：
Cell communication and signaling : CCS
影响因子：
--
作者：
Abfalter CM;Schubert M;Götz C;Schmidt TP;Posselt G;Wessler S
通讯作者：
Wessler S
DOI：
10.1073/pnas.0508936102
发表时间：
2005-12-06
影响因子：
11.1
作者：
Isaac, DD;Pinkner, JS;Silhavy, TJ
通讯作者：
Silhavy, TJ