Long-term repair of porcine articular cartilage using cryopreservable, clinically compatible human embryonic stem cell-derived chondrocytes.
Long-term repair of porcine articular cartilage using cryopreservable, clinically compatible human embryonic stem cell-derived chondrocytes.
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DOI：
10.1038/s41536-021-00187-3
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发表时间：
2021-11-23
影响因子：
7.2
通讯作者：
Evseenko D
中科院分区：
文献类型：
--
作者：
Petrigliano FA;Liu NQ;Lee S;Tassey J;Sarkar A;Lin Y;Li L;Yu Y;Geng D;Zhang J;Shkhyan R;Bogdanov J;Van Handel B;Ferguson GB;Lee Y;Hinderer S;Tseng KC;Kavanaugh A;Crump JG;Pyle AD;Schenke-Layland K;Billi F;Wang L;Lieberman J;Hurtig M;Evseenko D
Osteoarthritis (OA) impacts hundreds of millions of people worldwide, with those affected incurring significant physical and financial burdens. Injuries such as focal defects to the articular surface are a major contributing risk factor for the development of OA. Current cartilage repair strategies are moderately effective at reducing pain but often replace damaged tissue with biomechanically inferior fibrocartilage. Here we describe the development, transcriptomic ontogenetic characterization and quality assessment at the single cell level, as well as the scaled manufacturing of an allogeneic human pluripotent stem cell-derived articular chondrocyte formulation that exhibits long-term functional repair of porcine articular cartilage. These results define a new potential clinical paradigm for articular cartilage repair and mitigation of the associated risk of OA.
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DOI：
10.1002/stem.2691
发表时间：
2017-11
期刊：
Stem cells (Dayton, Ohio)
影响因子：
--
作者：
Dickinson SC;Sutton CA;Brady K;Salerno A;Katopodi T;Williams RL;West CC;Evseenko D;Wu L;Pang S;Ferro de Godoy R;Goodship AE;Péault B;Blom AW;Kafienah W;Hollander AP
通讯作者：
Hollander AP
影响因子：
9.7
作者：
Arzi B;DuRaine GD;Lee CA;Huey DJ;Borjesson DL;Murphy BG;Hu JCY;Baumgarth N;Athanasiou KA
通讯作者：
Athanasiou KA
影响因子：
5.2
作者：
Kidwai, Fahad;Mui, Byron W. H.;Robey, Pamela G.
通讯作者：
Robey, Pamela G.
影响因子：
4.8
作者：
Farr, Jack;Tabet, Samuel K.;Cole, Brian J.
通讯作者：
Cole, Brian J.
影响因子：
3.8
作者：
Basad, Erhan;Ishaque, Bernd;Steinmeyer, Juergen
通讯作者：
Steinmeyer, Juergen