Investigation of diets associated with dilated cardiomyopathy in dogs using foodomics analysis.
Investigation of diets associated with dilated cardiomyopathy in dogs using foodomics analysis.
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DOI：
10.1038/s41598-021-94464-2
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发表时间：
2021-08-05
影响因子：
4.6
通讯作者：
Freeman LM
中科院分区：
文献类型：
--
作者：
Smith CE;Parnell LD;Lai CQ;Rush JE;Freeman LM
扩张型心肌病（DCM）是一种影响人类和狗的心肌疾病。某些犬的饮食与扩张型心肌病有关，但饮食与疾病的联系尚无法解释，需要新的方法来阐明机制。我们对9种与犬DCM相关的饮食进行了代谢组学分析，这些饮食含有≥ 3种豆类、土豆或甘薯作为主要成分，并且是最常与向FDA报告的犬DCM病例相关的前16种犬饮食品牌（3 P/FDA饮食）和9种非3 P/FDA饮食。我们确定了88种在3 P/FDA饮食中较高的命名生化化合物和23种在3 P/FDA饮食中较低的命名化合物。氨基酸、氨基酸衍生化合物和异生物质/植物化合物是3 P/FDA饮食中含量较高的最大类别的生化物质。随机森林分析确定了前30种化合物，这些化合物以100%的预测准确率区分了两个饮食组。四种饮食成分区分两个饮食组（豌豆，扁豆，鸡肉/火鸡和米饭）。在这些成分中，豌豆显示出与3 P/FDA饮食中较高浓度化合物的最大关联。此外，目前的食物组学分析强调了犬的饮食和DCM之间的关系，可以确定可能的病因，以了解犬和人类的饮食-疾病关系。
Dilated cardiomyopathy (DCM) is a disease of the heart muscle that affects both humans and dogs. Certain canine diets have been associated with DCM, but the diet-disease link is unexplained, and novel methods are needed to elucidate mechanisms. We conducted metabolomic profiling of 9 diets associated with canine DCM, containing ≥ 3 pulses, potatoes, or sweet potatoes as main ingredients, and in the top 16 dog diet brands most frequently associated with canine DCM cases reported to the FDA (3P/FDA diets), and 9 non-3P/FDA diets. We identified 88 named biochemical compounds that were higher in 3P/FDA diets and 23 named compounds that were lower in 3P/FDA diets. Amino acids, amino acid-derived compounds, and xenobiotics/plant compounds were the largest categories of biochemicals that were higher in 3P/FDA diets. Random forest analyses identified the top 30 compounds that distinguished the two diet groups with 100% predictive accuracy. Four diet ingredients distinguished the two diet groups (peas, lentils, chicken/turkey, and rice). Of these ingredients, peas showed the greatest association with higher concentrations of compounds in 3P/FDA diets. Moreover, the current foodomics analyses highlight relationships between diet and DCM in dogs that can identify possible etiologies for understanding diet-disease relationships in dogs and humans.
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DOI：
10.1017/s0007114516002610
发表时间：
2016-09
期刊：
The British journal of nutrition
影响因子：
--
作者：
Grundy MM;Edwards CH;Mackie AR;Gidley MJ;Butterworth PJ;Ellis PR
通讯作者：
Ellis PR
影响因子：
7
作者：
Gibbons, Helena;Brennan, Lorraine
通讯作者：
Brennan, Lorraine
影响因子：
4.6
作者：
Kärkkäinen O;Tuomainen T;Koistinen V;Tuomainen M;Leppänen J;Laitinen T;Lehtonen M;Rysä J;Auriola S;Poso A;Tavi P;Hanhineva K
通讯作者：
Hanhineva K
影响因子：
6
作者：
J Verdonschot, Job A.;Wang, Ping;Bierau, Joergen
通讯作者：
Bierau, Joergen
影响因子：
6
作者：
Grube, Markus;Ameling, Sabine;Kroemer, Heyo K.
通讯作者：
Kroemer, Heyo K.