Acute flaccid myelitis a review of the literature.

Acute flaccid myelitis a review of the literature.
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DOI:
10.3389/fneur.2022.1034607
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发表时间:
2022
影响因子:
3.4
通讯作者:
--
中科院分区:
医学3区
文献类型:
--
作者:

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急性弛缓性脊髓炎(AFM)是一种罕见的神经系统疾病,于2014年首次引起全国关注。这种神经系统疾病每两年出现一次,每隔偶数年是高峰年。大多数患者出现在儿童期前驱感染后5天。患者通常在夏季或秋季表现为肌肉无力和低屈曲或反射。临床结果是可变的,但大多数患者没有改善。目前尚未发现明确的预后因素或病因。然而,人们认为肠病毒- d68 (EV-D68)可能是AFM病理生物学的一个潜在组成部分。治疗方案有限,有多种选择,没有共识。迄今为止,支持疗法已被证明是最有效的。通过对文献的回顾,我们强调了最近越来越多的证据表明EV-D68与AFM之间可能存在关系。此外,我们确定了AFM与治疗和预后因素的知识差距。
Acute flaccid myelitis (AFM) is a rare neurological disorder that first rose to national attention in 2014. This neurological disorder has a biennial presentation with every other even year being a peak year. Most patients present in childhood 5 days after a prodromal infection. Patients usually present with muscle weakness and hypo or areflexia in the summer or fall months. Clinical outcomes are variable however most patients do not improve. Currently there are no definitive prognostic factors or etiologies found. However, it is thought that enterovirus-D68 (EV-D68) could be a potential component in the pathobiology of AFM. Treatment options are limited with variable options and no consensus. Supportive therapy has been shown to be the most effective thus far. With our review of the literature, we highlight the recent growing evidence of a possible relationship between EV-D68 and AFM. Additionally, we identify the knowledge gaps in AFM with treatment and prognostic factors.
急性弛缓性脊髓炎儿童肠道病毒 D68 感染,美国科罗拉多州,2014 年。
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