Endometrial effects of a single early luteal dose of the selective progesterone receptor modulator CDB-2914.
Endometrial effects of a single early luteal dose of the selective progesterone receptor modulator CDB-2914.
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DOI：
10.1016/j.fertnstert.2008.12.057
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发表时间：
2010-04
影响因子：
6.7
通讯作者：
Nieman LK
中科院分区：
文献类型：
--
作者：
Stratton P;Levens ED;Hartog B;Piquion J;Wei Q;Merino M;Nieman LK
探讨选择性孕酮受体调节剂CDB-2914在黄体早期的潜在避孕机制。前瞻性随机临床试验。临床研究中心。五十六个经常骑车的女人。女性在排卵后和LH激增的两天内接受单剂量的CDB-2914（10，50或100 mg）或安慰剂。4 - 6天后，经阴道超声测量子宫内膜厚度并进行子宫内膜活检。通过厚度和对孕酮依赖性标记物的免疫组织化学评价子宫内膜;获得安全性实验室检查以及雌二醇和孕酮水平。CDB-2914引起子宫内膜厚度的显著剂量依赖性降低、腺孕酮受体的增加和外周淋巴结地址素的减少。雌二醇和孕酮水平和月经周期时间没有改变。未观察到不良反应。在激素水平和周期长度没有变化的情况下，子宫内膜厚度和孕酮依赖性着床标志物的改变表明CDB-2914可能具有避孕特性。
To test potential contraceptive mechanisms of the selective progesterone receptor modulator CDB-2914 in the early luteal phase. Prospective randomized clinical trial. Clinical Research Center. Fifty-six regularly cycling women. Women received a single dose of CDB-2914 (10, 50 or 100 mg) or placebo given after ovulation and within two days of the LH surge. Four to six days later, a transvaginal ultrasound measured endometrial thickness and an endometrial biopsy was obtained. The endometrium was evaluated by thickness and by immunohistochemistry for progesterone-dependent markers; safety laboratory tests, and estradiol and progesterone levels were obtained. CDB-2914 caused a significant dose-dependent decrease in endometrial thickness, an increase in glandular progesterone receptors, and a decrease in peripheral node addressins. Estradiol and progesterone levels and menstrual cycle timing were not altered. No adverse effects were observed. The alteration in endometrial thickness and progesterone dependent markers of implantation in the absence of changes in hormone levels and cycle length suggests that CDB-2914 may have contraceptive properties.
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影响因子：
6.1
作者：
GEMZELLDANIELSSON, K;SWAHN, ML;BYGDEMAN, M
通讯作者：
BYGDEMAN, M
影响因子：
6.1
作者：
Stratton, P;Hartog, B;Nieman, LK
通讯作者：
Nieman, LK
影响因子：
6.7
作者：
Coutifaris, C;Myers, ER;Leppert, PC
通讯作者：
Leppert, PC
影响因子：
3.1
作者：
Foulk, Russell A.;Zdravkovic, Tamara;Prakobphol, Akraporn
通讯作者：
Prakobphol, Akraporn
影响因子：
6.1
作者：
GEMZELLDANIELSSON, K;SVALANDER, P;BYGDEMAN, M
通讯作者：
BYGDEMAN, M