Treatment of gastrointestinal and renal adenocarcinomas with interferon-alpha.
Treatment of gastrointestinal and renal adenocarcinomas with interferon-alpha.
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用干扰素-α治疗胃肠道和肾腺癌。
DOI：
10.1007/bf02174204
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Ozer,H
中科院分区：
文献类型：
--
作者：
Meadows,LM;Lindley,C;Ozer,H
Treatment of adenocarcinomas with interferon-alpha as a single agent has been disappointing. Recent efforts have focused on the combination of interferon with cytotoxic drugs such as 5-fluorouracil. A number of postulated mechanisms can explain synergistic interactions between 5-fluorouracil and interferon-alpha, including interaction with pyrimidine pathways, and alteration of drug metabolism. Previous studies in colorectal cancer, using 5-fluorouracil and interferon-alpha are reviewed, suggesting that the combination is more active than 5-fluorouracil alone. In renal cell carcinoma, the literature is reviewed, suggesting that daily interferon is the most efficacious schedule; preliminary data suggest that addition of 5-fluorouracil to interferon-alpha can double the expected response rate of 16% achieved by interferon-alpha alone.
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