Cortical processing of location and frequency changes of sounds in normal hearing listeners.
Cortical processing of location and frequency changes of sounds in normal hearing listeners.
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正常听力者对声音位置和频率变化的皮层处理。
DOI：
10.1016/j.heares.2020.108110
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发表时间：
2021-03
期刊：
影响因子：
2.8
通讯作者：
Fu QJ
中科院分区：
文献类型：
--
作者：
Zhang F;McGuire K;Firestone G;Dalrymple K;Greinwald J;Fu QJ
我们在日常生活中听到的声音包含声学特征的变化（例如，频率、强度和持续时间或“什么”信息）和/或位置的变化（“哪里”信息）。本研究旨在探讨正常听力受试者的皮层听觉诱发电位（CAEP）对声音频率（F）和位置（L）的变化，即声变化复合波（ACC）。15名右利手的年轻听力正常的听众参加了脑电图（EEG）记录。声刺激是1秒的纯音（基频为250 Hz），在音调中间的位置（L，180°）、频率（F，5%和50%）或位置和频率（L+F）都有可感知的变化。此外，使用1秒的250 Hz音调（无任何变化）作为参考。参与者被要求被动地听刺激，并且在测试过程中不要移动他们的头。与仅引起起始CAEP的参考音相比，包含变化的音（L、F或L+F）引起起始CAEP和ACC。来自顶点电极（电极Cz）的ACC的波形分析显示，较大的声音变化引起较大的峰值幅度[例如，（L+50%F）- > L-变化;（L+50%F）- > 5%F-变化]和更短的峰值延迟（[（L+5%F）- <5%F-变化; 50%F- <5%F-变化;（L+50%F）- <5%F-变化]。ACC N1'峰的电流密度模式显示L变化与F变化之间的一些差异，支持对声音的“在哪里”和“什么”信息的不同皮层处理;无论声音变化的性质如何，较大的变化比较小的变化引起更强的激活[例如，L- > 5% F-变化;（L+5%F）- > 5%F-变化; 50%F- > 5%F-变化]，包括扣带回、内侧额回（MFG）、上级额回（SFG）、边缘叶扣带回和顶叶中央后回。结果表明，声音变化检测涉及基于记忆的声学比较（对声音变化的神经编码与存储在记忆中的改变前刺激的神经编码）和无意识注意转换。
Sounds we hear in our daily life contain changes in the acoustic features (e.g., frequency, intensity, and duration or “what” information) and/or changes in location (“where” information). The purpose of this study was to examine the cortical auditory evoked potentials (CAEPs) to the change within a stimulus, the acoustic change complex (ACC), in frequency (F) and location (L) of the sound in normal hearing listeners. Fifteen right-handed young normal hearing listeners participated in the electroencephalographic (EEG) recordings. The acoustic stimuli were pure tones (base frequency at 250 Hz) of 1 sec, with a perceivable change either in location (L, 180°), frequency (F, 5% and 50%), or both location and frequency (L+F) in the middle of the tone. Additionally, the 250 Hz tone of 1 sec without any change was used as a reference. The participants were asked to listen passively to the stimuli and not to move their heads during the testing. Compared to the reference tone, by which only the onset-CAEP was elicited, the tones containing changes (L, F, or L+F) elicited both onset-CAEP and the ACC. The waveform analysis of ACCs from the vertex electrode (electrode Cz) showed that, larger sound changes evoked larger peak amplitudes [e.g., (L+50%F)- > L-change; (L+50%F)- > 5%F-change] and shorter the peak latencies ([(L+5%F)- < 5%F-change; 50%F- < 5%F-change; (L+50%F)- < 5%F-change]. The current density patterns for the ACC N1’ peak displayed some differences between L-change vs. F-change, supporting different cortical processing for “where” and “what” information of the sound; regardless of the nature of the sound change, larger changes evoked a stronger activation than smaller changes [e.g., L- > 5%F-change; (L+5%F)- > 5%F-change; 50%F- > 5%F-change] in frontal lobe regions including the cingulate gyrus, medial frontal gyrus (MFG), superior frontal gyrus (SFG), the limbic lobe cingulate gyrus, and the parietal lobe postcentral gyrus. The results suggested that sound change-detection involves memory-based acoustic comparison (the neural encoding for the sound change vs. neural encoding for the pre-change stimulus stored in memory) and involuntary attention switch.
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