Polymer-Based Nitric Oxide Therapies: Recent Insights for Biomedical Applications.
Polymer-Based Nitric Oxide Therapies: Recent Insights for Biomedical Applications.
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DOI：
10.1002/adfm.201101707
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发表时间：
2012-01-25
影响因子：
19
通讯作者：
Ameer, Guillermo A.
中科院分区：
文献类型：
--
作者：
Jen, Michele C.;Serrano, Maria C.;van Lith, Robert;Ameer, Guillermo A.
自20世纪80年代发现一氧化氮（NO）以来，这种细胞信使已被证明参与多种生物过程，如心血管稳态，免疫反应，伤口愈合，骨代谢和神经传递。在过去的二十年里，其有益的影响促使了越来越多的研究，重点是开发可以局部释放NO的材料。这篇专题文章集中介绍释放和产生一氧化氮的高分子材料的发展（2006-2011），重点是最近的体内应用。结果进行了比较和讨论，在NO剂量，释放动力学和生物效应，以提供一个基础，设计和评估新的NO疗法。
Since the discovery of nitric oxide (NO) in the 1980s, this cellular messenger has been shown to participate in diverse biological processes such as cardiovascular homeostasis, immune response, wound healing, bone metabolism, and neurotransmission. Its beneficial effects have prompted increased research in the past two decades, with a focus on the development of materials that can locally release NO. However, significant limitations arise when applying these materials to biomedical applications. This Feature Article focuses on the development of NO-releasing and NO-generating polymeric materials (2006–2011) with emphasis on recent in vivo applications. Results are compared and discussed in terms of NO dose, release kinetics, and biological effects, in order to provide a foundation to design and evaluate new NO therapies.
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影响因子：
6.2
作者：
Coneski, Peter N.;Rao, Kavitha S.;Schoenfisch, Mark H.
通讯作者：
Schoenfisch, Mark H.
DOI：
10.1152/ajpheart.00665.2010
发表时间：
2011-01-01
影响因子：
4.8
作者：
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通讯作者：
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通讯作者：
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影响因子：
19.7
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
Meyerhoff, ME