Degradable nitric oxide-releasing biomaterials via post-polymerization functionalization of cross-linked polyesters.
Degradable nitric oxide-releasing biomaterials via post-polymerization functionalization of cross-linked polyesters.
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DOI：
10.1021/bm1006823
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发表时间：
2010-11-08
影响因子：
6.2
通讯作者：
Schoenfisch, Mark H.
中科院分区：
文献类型：
--
作者：
Coneski, Peter N.;Rao, Kavitha S.;Schoenfisch, Mark H.
描述了多种释放一氧化氮（NO）的网络聚酯的合成。多元醇与计算过量的二酸进行熔融相缩合，然后热固化生成含有酸端基的交联聚酯。改变聚酯的组成和固化温度可以得到具有可调热性能和降解性能的材料。合成材料的玻璃化转变温度范围为 -25.5 °C 至 3.2 °C，而这些聚酯在生理条件（pH 7.4，37 °C）下至少九周内就会完全降解。氨基硫醇与末端羧酸的聚合后偶联生成含硫醇的聚酯，其热和降解特性与母体聚酯相似。亚硝化后，这些材料能够在长达 6 d 的时间内释放高达 0.81 μmol NO cm−2 。与未修饰的对照相比，铜绿假单胞菌粘附减少了 80%，表明聚酯作为抗菌生物材料的实用性。
The synthesis of diverse nitric oxide (NO)-releasing network polyesters is described. The melt phase condensation of polyols with a calculated excess of diacid followed by thermal curing generates crosslinked polyesters containing acid end groups. Varying the composition and curing temperatures of the polyesters resulted in materials with tunable thermal and degradation properties. Glass transition temperatures for the synthesized materials range from −25.5 °C to 3.2 °C, while complete degradation of these polyesters occurs within a minimum of nine weeks under physiological conditions (pH 7.4, 37 °C). Post-polymerization coupling of aminothiols to terminal carboxylic acids generate thiol-containing polyesters, with thermal and degradation characteristics similar to those of the parent polyesters. After nitrosation, these materials are capable of releasing up to 0.81 μmol NO cm−2 for up to 6 d. The utility of the polyesters as antibacterial biomaterials was indicated by an 80% reduction of Pseudomonas aeruginosa adhesion compared to unmodified controls.
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影响因子：
14
作者：
Hetrick, Evan M.;Shin, Jae Ho;Paul, Heather S.;Schoenfisch, Mark H.
通讯作者：
Schoenfisch, Mark H.
影响因子：
5.5
作者：
Barrett, Devin G.;Yousaf, Muhammad N.
通讯作者：
Yousaf, Muhammad N.
影响因子：
17.1
作者：
Hetrick, Evan M.;Shin, Jae Ho;Schoenfisch, Mark H.
通讯作者：
Schoenfisch, Mark H.
影响因子：
6.2
作者：
Jun, HW;Taite, LJ;West, JL
通讯作者：
West, JL
影响因子：
2.2
作者：
Lee, RH;Efron, D;Barbul, A
通讯作者：
Barbul, A