Evaluating functional localizers: the case of the FFA.

Evaluating functional localizers: the case of the FFA.
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DOI:
10.1016/j.neuroimage.2009.12.024
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发表时间:
2010-03
期刊:
影响因子:
5.7
通讯作者:
Jonides, John
Jonides, John
中科院分区:
医学1区
文献类型:
--
作者:
Berman, Marc G.;Park, Joonkoo;Gonzalez, Richard;Polk, Thad A.;Gehrke, Amanda;Knaffla, Scott;Jonides, John

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在神经影像学研究中,功能性定位器通常被用于检验有关特定大脑区域功能的假设。即使针对的是同一皮质区域,不同研究中用于定位特定区域的具体任务和刺激也存在很大差异。因此,重要的是要探究任务和刺激的变化是否会导致定位的差异,或者定位程序是否在很大程度上不受任务和对比刺激差异的影响。我们进行了两项实验并做了一篇文献综述,以探究面部定位任务是否会根据任务和对比刺激的不同而在梭状回产生不同的定位。我们测试了标准的定位任务——被动观看、1-back和2-back记忆测试——并且未发现基于任务的定位差异。然而,我们确实发现基于对比刺激(面部与房屋对比面部与杂乱刺激),梭状回的激活程度、强度以及模式/可靠性存在差异。
Functional localizers are routinely used in neuroimaging studies to test hypotheses about the function of specific brain areas. The specific tasks and stimuli used to localize particular regions vary widely from study to study even when the same cortical region is targeted. Thus, it is important to ask whether task and stimulus changes lead to differences in localization or whether localization procedures are largely immune to differences in tasks and contrasting stimuli. We present two experiments and a literature review that explore whether face localizer tasks yield differential localization in the fusiform gyrus as a function of task and contrasting stimuli. We tested standard localization tasks---passive viewing, 1-back, and 2-back memory tests---and did not find differences in localization based on task. We did, however, find differences in the extent, strength and patterns/reliabilities of the activation in the fusiform gyrus based on comparison stimuli (faces vs. houses compared to faces vs. scrambled stimuli).
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