Enhancement of ventricular-subventricular zone-derived neurogenesis and oligodendrogenesis by erythropoietin and its derivatives.
Enhancement of ventricular-subventricular zone-derived neurogenesis and oligodendrogenesis by erythropoietin and its derivatives.
复制标题
DOI：
10.3389/fncel.2013.00235
复制
发表时间：
2013-11-27
影响因子：
5.3
通讯作者：
Sawamoto K
中科院分区：
文献类型：
--
作者：
Kaneko N;Kako E;Sawamoto K
在出生后的哺乳动物脑中，脑室-脑室下区（V-SVZ）的干细胞在整个生命过程中不断产生神经元和神经胶质细胞。特定谱系细胞的遗传标记已经证明V-SVZ是神经母细胞和/或少突胶质细胞祖细胞（OPC）的重要来源，所述神经母细胞和/或少突胶质细胞祖细胞响应于几种类型的损伤（包括缺血和脱髓鞘疾病）而向受损的脑区域迁移。然而，这种自发性再生不足以完全恢复受损大脑的结构和功能，因此正在寻求用于临床应用的干预措施来增强这些过程。促红细胞生成素（EPO）是一种临床应用的促红细胞生成因子，对中枢神经系统的各种损伤具有细胞保护作用。此外，最近的研究表明，EPO促进V-SVZ源性神经发生和少突神经发生。EPO增加V-SVZ中祖细胞的增殖和/或其后代在损伤区域内和周围的迁移和分化，这取决于治疗的剂量、时间和持续时间以及所用动物模型的类型。另一方面，EPO具有不期望的副作用，包括血栓形成并发症。我们最近证明，用EPO衍生物脱唾液酸EPO治疗2周可促进新生小鼠受损白色物质中V-SVZ衍生的OPC分化为髓鞘形成的成熟少突胶质细胞，而不引起红细胞生成。在这里，我们提出了EPO及其衍生物在V-SVZ中的多方面作用的概述，并讨论了这些分子在再生医学中的可能应用。
In the postnatal mammalian brain, stem cells in the ventricular-subventricular zone (V-SVZ) continuously generate neuronal and glial cells throughout life. Genetic labeling of cells of specific lineages have demonstrated that the V-SVZ is an important source of the neuroblasts and/or oligodendrocyte progenitor cells (OPCs) that migrate toward injured brain areas in response to several types of insult, including ischemia and demyelinating diseases. However, this spontaneous regeneration is insufficient for complete structural and functional restoration of the injured brain, so interventions to enhance these processes are sought for clinical applications. Erythropoietin (EPO), a clinically applied erythropoietic factor, is reported to have cytoprotective effects in various kinds of insult in the central nervous system. Moreover, recent studies suggest that EPO promotes the V-SVZ-derived neurogenesis and oligodendrogenesis. EPO increases the proliferation of progenitors in the V-SVZ and/or the migration and differentiation of their progenies in and around injured areas, depending on the dosage, timing, and duration of treatment, as well as the type of animal model used. On the other hand, EPO has undesirable side effects, including thrombotic complications. We recently demonstrated that a 2-week treatment with the EPO derivative asialo-EPO promotes the differentiation of V-SVZ-derived OPCs into myelin-forming mature oligodendrocytes in the injured white matter of neonatal mice without causing erythropoiesis. Here we present an overview of the multifaceted effects of EPO and its derivatives in the V-SVZ and discuss the possible applications of these molecules in regenerative medicine.
登录
查看更多内容
影响因子：
5
作者：
Banks, WA;Jumbe, NL;Heatherington, AC
通讯作者：
Heatherington, AC
DOI：
10.1073/pnas.1031753100
发表时间：
2003-05-27
影响因子：
11.1
作者：
Erbayraktar, S;Grasso, G;Brines, M
通讯作者：
Brines, M
影响因子：
4.1
作者：
Belvindrah, Richard;Lazarini, Francoise;Lledo, Pierre-Marie
通讯作者：
Lledo, Pierre-Marie
DOI：
10.1097/00004647-199906000-00007
发表时间：
1999-06-01
影响因子：
6.3
作者：
Bernaudin, M;Marti, HH;Petit, E
通讯作者：
Petit, E
影响因子：
3.6
作者：
Fan, Xiyong;Heijnen, Cob J.;van Bel, Frank
通讯作者：
van Bel, Frank