Candidate Polymorphisms and Susceptibility to Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis.
Candidate Polymorphisms and Susceptibility to Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis.
复制标题
候选多态性和炎症性肠病的易感性：系统评价和荟萃分析。
DOI：
10.1016/j.gene.2020.144814
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发表时间：
2020
期刊：
影响因子：
3.5
通讯作者：
Mengque Xu
中科院分区：
文献类型：
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作者：
Linlin Tang;Mengque Xu
目的探讨13个单核苷酸多态性与炎症性肠病（IBD）的关系，包括克罗恩病（Crohn's disease，CD）和溃疡性结肠炎（Ulcerative colitis，UC）。结果经系统筛选后，从44篇文献中筛选出13个单核苷酸多态性（singlenucleotide polymorphisms，SNPs）。我们的研究结果表明，发现3个SNP与CD/UC/IBD显著相关：IRF 5 rs 4728142（UC：亚裔OR = 1.21，95% CI = 1.09-1.35，P = 0.0003; OR = 1.30，95% CI = 1.08-1.57，P = 0.006），PTGER 4 rs 4613763（CD：总体OR = 1.28，95%CI = 1.01-1.64，P = 0.04; IBD：OR = 1.31，95%CI = 1.04-1.65，P = 0.02），IL 12 Brs6887695（CD：总体OR = 1.17，95%CI = 1.06-1.30，P = 0.002; UC：总体OR = 1.13，95%CI = 1.01-1.26，P = 0.03; IBD：总体OR = 1.13，95%CI = 1.01-1.26，P = 0.03）总OR = 1.15，95%CI = 1.06-1.24，P = 0.0009）。结论单核苷酸多态性（IRF 5 rs 4728142、PTGER 4 rs 4613763和IL 12 Brs 6887695）与CD/UC/IBD有显著相关性。
AimsThe goal of our study is to investigate the contribution of the 13 single-nucleotide polymorphisms to inflammatory bowel disease (IBD), including Crohn’s disease (CD) and Ulcerative colitis (UC).MethodsA total of 44 articles were retrieved from bibliographic databases including PubMed, Embase, SpingerLink, Web of Science, Chinese National Knowledge Infrastructure (CNKI), and Wanfang. Through a comprehensive filtering procedure, 13 single-nucleotide polymorphisms were collected in themeta-analysis, which was done by Review Manager 5.0.ResultsAfter a systematic filtration, there were 13 single-nucleotide polymorphisms (SNPs) from 44 articles involved in ourmeta-analysis. Our results demonstrated that 3 SNPs were found to be significantly associated with CD/UC/IBD:IRF5rs4728142 (UC: OR = 1.21, 95% CI = 1.09–1.35, P = 0.0003; OR = 1.30, 95% CI = 1.08–1.57, P = 0.006 in Asian),PTGER4rs4613763 (CD: the overall OR = 1.28, 95% CI = 1.01–1.64, P = 0.04; IBD: OR = 1.31, 95% CI = 1.04–1.65, P = 0.02),IL12Brs6887695 (CD: the overall OR = 1.17, 95% CI = 1.06–1.30, P = 0.002; UC: the overall OR = 1.13, 95% CI = 1.01–1.26, P = 0.03; IBD: the overall OR = 1.15, 95% CI = 1.06–1.24, P = 0.0009).ConclusionOurmeta-analyses have indicated the significant associations between SNPs (IRF5rs4728142,PTGER4rs4613763, andIL12Brs6887695) and CD/UC/IBD.
影响因子：
29.4
作者：
Huang C;Haritunians T;Okou DT;Cutler DJ;Zwick ME;Taylor KD;Datta LW;Maranville JC;Liu Z;Ellis S;Chopra P;Alexander JS;Baldassano RN;Cross RK;Dassopoulos T;Dhere TA;Duerr RH;Hanson JS;Hou JK;Hussain SZ;Isaacs KL;Kachelries KE;Kader H;Kappelman MD;Katz J;Kellermayer R;Kirschner BS;Kuemmerle JF;Kumar A;Kwon JH;Lazarev M;Mannon P;Moulton DE;Osuntokun BO;Patel A;Rioux JD;Rotter JI;Saeed S;Scherl EJ;Silverberg MS;Silverman A;Targan SR;Valentine JF;Wang MH;Simpson CL;Bridges SL;Kimberly RP;Rich SS;Cho JH;Rienzo AD;Kao LWH;McGovern DPB;Brant SR;Kugathasan S
通讯作者：
Kugathasan S
DOI：
10.1016/0197-2456(90)90005-m
发表时间：
1990-04-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
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作者：
DUPONT, WD;PLUMMER, WD
通讯作者：
PLUMMER, WD