Effect of bulk modulus on deformation of the brain under rotational accelerations.
Effect of bulk modulus on deformation of the brain under rotational accelerations.
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DOI：
10.1007/s00193-017-0791-z
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发表时间：
2018-01
期刊：
影响因子：
2.2
通讯作者：
Ramesh KT
中科院分区：
文献类型：
--
作者：
Ganpule S;Daphalapurkar NP;Cetingul MP;Ramesh KT
创伤性脑损伤，如爆炸的后果，是一种复杂的损伤与广泛的症状和残疾。脑生物力学的计算模型有望阐明创伤性脑损伤（TBI）的机制和开发预防性设备。然而，可靠的材料参数是模型预测所必需的。不幸的是，人脑组织的性质难以测量，并且特别是脑组织的体积模量没有很好地表征。因此，在脑生物力学的计算模型中使用了宽范围的体积模量值，值之间的差异跨越高达三个数量级。然而，这些变化对计算预测的敏感性尚不清楚。在这项工作中，我们研究了一个3D计算人的头部模型的各种体积模量值的敏感性。从T1加权MRI图像以2 mm3体素分辨率构建受试者特定的人头部模型。扩散张量成像提供了轴突纤维束的空间分布和方向的数据，用于模拟白质各向异性。人类志愿者的非损伤性全视野脑变形被用于评估模拟预测。比较表明，在GPa的顺序上的体积模量值给出了最好的协议与实验测量的在人体大脑中的体内变形。此外，有害载荷的模拟表明，GPa量级的体积模量值在预测的损伤区域和损伤程度方面与临床结果最接近。
Traumatic brain injury such as that developed as a consequence of blast is a complex injury with a broad range of symptoms and disabilities. Computational models of brain biomechanics hold promise for illuminating the mechanics of traumatic brain injury (TBI) and for developing preventive devices. However, reliable material parameters are needed for models to be predictive. Unfortunately, the properties of human brain tissue are difficult to measure, and the bulk modulus of brain tissue in particular is not well-characterized. Thus, a wide range of bulk modulus values are used in computational models of brain biomechanics, spanning up to three orders of magnitude in the differences between values. However, the sensitivity of these variations on computational predictions is not known. In this work, we study the sensitivity of a 3D computational human head model to various bulk modulus values. A subject-specific human head model was constructed from T1-weighted MRI images at 2 mm3 voxel resolution. Diffusion tensor imaging provided data on spatial distribution and orientation of axonal fiber-bundles for modeling white-matter anisotropy. Non-injurious, full-field brain deformations in a human volunteer were used to assess the simulated predictions. The comparison suggests that a bulk modulus value on the order of GPa gives the best agreement with experimentally measured in vivo deformation in the human brain. Further, simulations of injurious loading suggest that bulk modulus values on the order of GPa provide the closest match with the clinical findings in terms of predicated injured regions and extent of injury.
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影响因子：
17.1
作者：
Goldstein LE;Fisher AM;Tagge CA;Zhang XL;Velisek L;Sullivan JA;Upreti C;Kracht JM;Ericsson M;Wojnarowicz MW;Goletiani CJ;Maglakelidze GM;Casey N;Moncaster JA;Minaeva O;Moir RD;Nowinski CJ;Stern RA;Cantu RC;Geiling J;Blusztajn JK;Wolozin BL;Ikezu T;Stein TD;Budson AE;Kowall NW;Chargin D;Sharon A;Saman S;Hall GF;Moss WC;Cleveland RO;Tanzi RE;Stanton PK;McKee AC
通讯作者：
McKee AC
影响因子：
4.2
作者：
Ji, Songbai;Zhao, Wei;McAllister, Thomas W.
通讯作者：
McAllister, Thomas W.
影响因子：
3.5
作者：
Ganpule, S.;Alai, A.;Chandra, N.
通讯作者：
Chandra, N.
影响因子：
2.6
作者：
Doll, S;Schweizerhof, K
通讯作者：
Schweizerhof, K
影响因子：
3.5
作者：
Goriely A;Geers MG;Holzapfel GA;Jayamohan J;Jérusalem A;Sivaloganathan S;Squier W;van Dommelen JA;Waters S;Kuhl E
通讯作者：
Kuhl E