Effects of slow, sustained, and rate-tunable nitric oxide donors on human aortic smooth muscle cells proliferation.
Effects of slow, sustained, and rate-tunable nitric oxide donors on human aortic smooth muscle cells proliferation.
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DOI：
10.1111/j.1747-0285.2011.01174.x
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发表时间：
2011-10
影响因子：
3
通讯作者：
Mohanty DK
中科院分区：
文献类型：
--
作者：
Yu H;Payne TJ;Mohanty DK
Smooth muscle cell (SMC) proliferation has been accepted as a common event in the pathophysiology of vascular diseases, including atherogenesis and intimal hyperplasia. Delivery of the nitric oxide synthase (NOS) substrate L-arginine, pharmacological nitric oxide (NO) donors, NO gas or over-expression of NOS proteins can inhibit SMC proliferation and reduce the injury responses within the blood vessel wall. Though commercial development of NO-donors that attempt to provide exogenous delivery of NO has accelerated over the last few years. None of the currently available products can provide controlled, sustained, time tunable release of NO. Nitrosamine-based NO donors, prepared in our laboratory, present a unique and innovative alternative for possible treatments for long-term NO deficiency related diseases including atherosclerosis, asthma, erectile dysfunction, cancer and neurodegenerative diseases. A family of secondary amines prepared via nucleophilic aromatic displacement reactions could be readily N-nitrosated to produce NO donors. NO release takes place in three distinct phases. During the initial phase, the release rate is extremely fast. In the second phase, the release is slower and the rate remains essentially the same during the final stage. These compounds inhibited up to 35% human aortic smooth muscle cell (HASMC) proliferation in a concentration-dependent manner.
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影响因子：
64.8
作者：
PALMER, RMJ;ASHTON, DS;MONCADA, S
通讯作者：
MONCADA, S
DOI：
10.1073/pnas.071054698
发表时间：
2001-03-27
影响因子：
11.1
作者：
Ignarro, LJ;Buga, GM;del Soldato, P
通讯作者：
del Soldato, P
影响因子：
15.9
作者：
Bouley, R;Breton, S;Brown, D
通讯作者：
Brown, D
影响因子：
64.8
作者：
HUANG, PL;HUANG, ZH;FISHMAN, MC
通讯作者：
FISHMAN, MC
影响因子：
7.3
作者：
RADOMSKI, MW;PALMER, RMJ;MONCADA, S
通讯作者：
MONCADA, S