Immunology of amyloid disease: a review.
Immunology of amyloid disease: a review.
复制标题
淀粉样蛋白疾病的免疫学：综述。
DOI：
10.1016/0049-0172(77)90019-1
复制
发表时间：
1977
影响因子：
5
通讯作者：
M. Scheinberg
中科院分区：
文献类型：
--
作者：
M. Scheinberg
A包括一组具有多种临床特征的疾病，其特征是在身体各组织中细胞外沉积一种蛋白质、无定形和嗜酸性物质。所有淀粉样蛋白沉积物的共同点是纤维状结构的存在；这些原纤维负责刚果红染色，二色性和绿色偏振色，通过组织学鉴定淀粉样蛋白沉积。淀粉样蛋白原纤维对蛋白水解消化的抵抗及其不溶性表明，它们对重要组织的破坏和多器官衰竭负责，导致肾或心力衰竭死亡。本文的目的是总结最近支持免疫机制参与淀粉样蛋白病发病机制的免疫化学和细胞方面的观点。这些研究的意义与淀粉样蛋白原纤维的发生有关，似乎为治疗这种经常致命的疾病开辟了新的途径。为了更完整地讨论过去对淀粉样变性的研究和这种疾病的临床表现，读者可以参考其他综述文章
A includes a group of diseases with a variety of clinical features characterized by the extracellular deposition of a proteinaceous, amorphous, and eosinophilic material in the various tissues of the body. Common to all amyloid deposits is the presence of a fibrillar structure; these fibrils are responsible for the Congo red staining, dichroism, and green polarization color by which amyloid deposits are identified histologically. The resistance to proteolytic digestion of amyloid fibrils and their insolubility indicate that they are responsible for the destruction of vital tissues and multiple organ failure that leads to death from renal or cardiac failure.The purpose of this paper is to summarize the recent immunochemical and cellular aspects that support the notion that immunologic mechanisms are involved in the pathogenesis of amyloid disease. The implications of these studies are relevant to the genesis of amyloid fibrils and appear to open new approaches to the therapy of this often fatal disease. For a more complete discussion of the past research on amyloidosis and the clinical manifestations of this disease the reader is referred to other review papers.‘~-‘j
淀粉样蛋白相关血清蛋白SAA在内毒素诱导的水貂淀粉样变性中的作用
影响因子：
15.3
作者：
R. Anders;K. Nordstoga;J. Natvig;G. Husby
通讯作者：
G. Husby