Age and hemispheric differences in transcallosal inhibition between motor cortices: an ispsilateral silent period study.
Age and hemispheric differences in transcallosal inhibition between motor cortices: an ispsilateral silent period study.
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DOI：
10.1186/1471-2202-14-62
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发表时间：
2013-06-25
期刊：
影响因子：
2.4
通讯作者：
Tremblay F
中科院分区：
文献类型：
--
作者：
Davidson T;Tremblay F
在这项研究中，我们研究了在同侧沉默期（iSP）主动收缩的情况下，跨胼胝体抑制（TCI）的年龄和半球差异。我们还研究了TCI的年龄相关变化是否与相应的手动性能随年龄的变化有关。参与者包括两个年龄组的右撇子（年轻人，n=13；老年人，n=17）。当另一只手的同类肌肉轻微收缩时（最大收缩量的约15%），通过在最大收缩手同侧的初级运动皮层传递的阈上TMS脉冲测量每个半球的iSP。手动性能评估双方的握力和精细灵巧。我们的结果产生了两个主要发现。首先，从iSP得出的TCI测量值受到年龄的强烈影响，而半球之间的差异只有很小。其次，相关分析显示，TCI测量的年龄相关变化与手动性能的变化有关，因此从左到右TCI与右手性能相关，反之亦然。总的来说，这些结果与最近的其他报告一致，表明运动皮质之间的相互抑制倾向于随着年龄的增长而下降。在这方面，我们的观察结果与运动皮层之间通常主要抑制性相互作用的平衡随着年龄的增长而向兴奋性过程转移的观点一致。
In this study, we investigated age and hemispheric differences in transcallosal inhibition (TCI) in the context of active contraction using the ipsilateral silent period (iSP). We also examined whether age-related changes in TCI would be related to corresponding changes in manual performance with age. Participants consisted of right-handed individuals from two age groups (young adults, n=13; seniors, n=17). The iSP was measured for each hemisphere using suprathreshold TMS pulses delivered over the primary motor cortex ipsilateral to the maximally contracting hand while the homologue muscles of the opposite hand were lightly contracting (~15% of the maximum). Manual performance was assessed bilaterally for both grip strength and fine dexterity. Our results yielded two main findings. First, TCI measures derived from iSP were strongly influenced by age, whereas differences between hemispheres were only minor. Second, correlation analyses revealed that age-related variations in TCI measures were related to changes in manual performance, so that left-to-right TCI correlated with right hand performance and vice-versa for the opposite hand/hemisphere. Overall, these results concur with other recent reports indicating that mutual inhibition between motor cortices tends to decline with age. In this respect, our observations are in line with the notion that the balance of normally predominantly inhibitory interactions between motor cortices is shifted toward excitatory processes with age.
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