Association between kidney function and telomere length: the heart and soul study.
Association between kidney function and telomere length: the heart and soul study.
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DOI：
10.1159/000343495
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发表时间：
2012
影响因子：
4.2
通讯作者：
Hsu CY
中科院分区：
文献类型：
--
作者：
Bansal N;Whooley MA;Regan M;McCulloch CE;Ix JH;Epel E;Blackburn E;Lin J;Hsu CY
端粒磨损是心血管疾病的一个新的危险因素。端粒长度与肾功能关系的研究有限。我们探讨了肾功能与端粒长度和端粒缩短的关系。心脏和灵魂研究是一项针对稳定型冠心病（CHD）患者的纵向研究。基线肾功能指标包括：血清肌酐、肌酐衍生的估计肾小球滤过率（eGFRCKD-EPI）、24小时尿肌酐清除率、胱抑素C、胱抑素C衍生的估计肾小球滤过率（eGFRcys）和尿白蛋白/肌酐比值。在基线（N=954）和5年后（N=608）从外周血白细胞测量端粒长度。使用线性回归模型来检验肾功能与i）基线端粒长度和ii）5年内端粒长度变化的相关性。基线时，平均eGFRCKD-EPI为72.6（± 21.5）ml/min/1.73 m2，eGFRcys为71.0（± 23.1）ml/min/1.73 m2，ACR为8.6（±12.3）mg/gm。只有较低的基线eGFRCKD-EPI与较短的基线端粒长度相关（eGFRCKD-EPI每降低5 ml/min/1.73 m2，碱基对减少9.1 [95% CI 1.2-16.9]）。较低的基线eGFRCKD-EPI（和所有其他肾功能指标）预测端粒缩短更快（eGFRCKD-EPI每降低5 ml/min/1.73 m2，5年内碱基对减少10.8 [95% CI 4.3-17.3]）。经年龄调整后，这些关联不再具有统计学意义。在CHD患者中，肾功能降低与i）基线端粒长度较短和ii）5年内端粒缩短更快相关，但这些相关性完全由年龄较大解释。
Telomere attrition is a novel risk factor for cardiovascular disease. Studies of telomere length in relation to kidney function are limited. We explored the association of kidney function with telomere length and telomere shortening. The Heart and Soul study is a longitudinal study of patients with stable coronary heart disease (CHD). Measures of baseline kidney function included: serum creatinine, creatinine-derived estimated glomerular filtration rate (eGFRCKD-EPI), 24-hour urine measured creatinine clearance, cystatin C, cystatin C-derived estimated glomerular filtration rate (eGFRcys) and urine albumin to creatinine ratio. Telomere length was measured from peripheral blood leukocytes at baseline (N=954) and 5 years later (N=608). Linear regression models were used to test the association of kidney function with i) baseline telomere length and ii) change in telomere length over 5 years. At baseline, mean eGFRCKD-EPI was 72.6 (± 21.5) ml/min/1.73 m2, eGFRcys was 71.0 (± 23.1) ml/min/1.73 m2 and ACR was 8.6 (±12.3) mg/gm. Only lower baseline eGFRCKD-EPI was associated with shorter baseline telomere length (9.1 [95% CI 1.2–16.9] fewer base pairs for every 5 ml/min/1.73 m2 lower eGFRCKD-EPI). Lower baseline eGFRCKD-EPI (and all other measures of kidney function) predicted more rapid telomere shortening (10.8 [95% CI 4.3–17.3] decrease in base pairs over 5 years for every 5 ml/min/1.73 m2 lower eGFRCKD-EPI). After adjustment for age, these associations were no longer statistically significant. In patients with CHD, reduced kidney function is associated with i) shorter baseline telomere length and ii) more rapid telomere shortening over 5 years, however these associations are entirely explained by older age.
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影响因子：
3.7
作者：
Farzaneh-Far R;Lin J;Epel E;Lapham K;Blackburn E;Whooley MA
通讯作者：
Whooley MA
DOI：
10.1007/s00392-009-0048-7
发表时间：
2009-10
期刊：
Clinical research in cardiology : official journal of the German Cardiac Society
影响因子：
--
作者：
Wong LS;van der Harst P;de Boer RA;Codd V;Huzen J;Samani NJ;Hillege HL;Voors AA;van Gilst WH;Jaarsma T;van Veldhuisen DJ
通讯作者：
van Veldhuisen DJ
影响因子：
13.2
作者：
Ramírez, R;Carracedo, J;Aljama, P
通讯作者：
Aljama, P
影响因子：
2.8
作者：
van der Harst, Pim;Wong, Liza S. M.;van Veldhuisen, Dirk J.
通讯作者：
van Veldhuisen, Dirk J.
影响因子：
13.2
作者：
Stevens, Lesley A.;Coresh, Josef;Levey, Andrew S.
通讯作者：
Levey, Andrew S.