Renal dysfunction is associated with shorter telomere length in heart failure.
Renal dysfunction is associated with shorter telomere length in heart failure.
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DOI：
10.1007/s00392-009-0048-7
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发表时间：
2009-10
期刊：
影响因子：
--
通讯作者：
van Veldhuisen DJ
中科院分区：
文献类型：
--
作者：
Wong LS;van der Harst P;de Boer RA;Codd V;Huzen J;Samani NJ;Hillege HL;Voors AA;van Gilst WH;Jaarsma T;van Veldhuisen DJ
肾功能障碍是慢性心力衰竭（CHF）患者中一种常见的与高死亡率相关的合并症。内在生物年龄可能会影响肾脏应对CHF引起的挑战性环境的能力。我们探讨了白细胞端粒长度（生物学年龄的标志）与CHF患者肾功能之间的关系。通过实时定量聚合酶链反应测定866例CHF患者的端粒长度。用肾脏疾病方程中饮食的简化修改来估计肾功能。中位年龄为74岁（四分位数范围64-79），61%为男性，左室射血分数为30(23-44)%，肾小球滤过率估计为53 (40-68)ml/min/1.73 m2。端粒长度与肾功能相关（相关系数0.123,P < 0.001）。在校正了年龄、性别、CHF发病年龄后，这一关系仍然显著（标准化β - 0.091, P = 0.007）。另外，调整CHF的严重程度和基线差异也没有改变我们的发现。心衰患者白细胞端粒长度缩短与肾功能下降之间的关系表明，内在的生物老化影响肾脏应对心力衰竭引起的全身变化的能力。
Renal dysfunction is a frequent comorbidity associated with high mortality in patients with chronic heart failure (CHF). The intrinsic biological age might affect the ability of the kidney to cope with the challenging environment caused by CHF. We explored the association between leukocyte telomere length, a marker for biological age, and renal function in patients with CHF. Telomere length was determined by a real-time quantitative polymerase chain reaction in 866 CHF patients. Renal function was estimated with the simplified Modification of Diet in Renal Disease equation. The median age was 74 (interquartile range 64–79) years, 61% male, left ventricular ejection fraction of 30 (23–44)%, and the estimated glomerular filtration rate was 53 (40–68) ml/min/1.73 m2. Telomere length was associated with renal function (correlation coefficient 0.123, P < 0.001). This relationship remained significant after adjustment for age, gender, age of CHF onset (standardized-beta 0.091, P = 0.007). Also additionally adjusting for the severity of CHF and baseline differences did not change our findings. The association between shorter leukocyte telomere length and reduced renal function in heart failure suggests that intrinsic biological aging affects the ability of the kidney to cope with the systemic changes evoked by heart failure.
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