Epigenetic dysregulation of the dopamine system in diet-induced obesity.
Epigenetic dysregulation of the dopamine system in diet-induced obesity.
复制标题
DOI：
10.1111/j.1471-4159.2012.07649.x
复制
发表时间：
2012-03
影响因子：
4.7
通讯作者：
Reyes TM
中科院分区：
文献类型：
--
作者：
Vucetic Z;Carlin JL;Totoki K;Reyes TM
Chronic intake of high fat diet is known to alter brain neurotransmitter systems that participate in the central regulation of food intake. Dopamine (DA) system changes in response to high fat diet have been observed in the hypothalamus, important in the homeostatic control of food intake, as well as within the central reward circuitry (ventral tegmental area (VTA), nucleus accumbens (NAc) and prefrontal cortex (PFC)), critical for coding the rewarding properties of palatable food and important in hedonically-driven feeding behavior. Using a mouse model of diet-induced obesity (DIO), significant alterations in expression in dopamine-related genes were documented in adult animals, and the general pattern of gene expression changes was opposite within the hypothalamus versus the reward circuitry (increased versus decreased, respectively). Differential DNA methylation was identified within the promoter regions of tyrosine hydroxylase (TH) and dopamine transporter (DAT) and the pattern of this response was consistent with the pattern of gene expression. Behaviors consistent with increased hypothalamic DA and decreased reward circuitry DA were observed. These data identify differential DNA methylation as an epigenetic mechanism linking chronic intake of high fat diet with altered dopamine-related gene expression, and this response varies by brain region and DNA sequence.
登录
查看更多内容
DOI：
10.1523/jneurosci.1786-08.2008
发表时间：
2008-10-15
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Lubin FD;Roth TL;Sweatt JD
通讯作者：
Sweatt JD
影响因子：
3.3
作者：
Rada, P;Avena, NM;Hoebel, BG
通讯作者：
Hoebel, BG
影响因子：
2.9
作者：
Rada, Pedro;Bocarsly, Miriam E.;Barson, Jessica R.;Hoebel, Bartley G.;Leibowitz, Sarah F.
通讯作者：
Leibowitz, Sarah F.
DOI：
10.1016/s0736-5748(96)00121-9
发表时间：
1997-04-01
影响因子：
1.8
作者：
Chen, JC;Turiak, G;Volicer, L
通讯作者：
Volicer, L
食物摄入的昼夜节律时间有助于体重增加。
影响因子：
6.9
作者：
Arble, Deanna M.;Bass, Joseph;Laposky, Aaron D.;Vitaterna, Martha H.;Turek, Fred W.
通讯作者：
Turek, Fred W.