Circadian timing of food intake contributes to weight gain.

Circadian timing of food intake contributes to weight gain.
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食物摄入的昼夜节律时间有助于体重增加。

DOI:
10.1038/oby.2009.264
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发表时间:
2009-11
期刊:
影响因子:
6.9
通讯作者:
Turek, Fred W.
Turek, Fred W.
中科院分区:
医学2区
文献类型:
--
作者:
Arble, Deanna M.;Bass, Joseph;Laposky, Aaron D.;Vitaterna, Martha H.;Turek, Fred W.

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体重调节的研究几乎完全集中在热量摄入和能量消耗上。然而,最近在动物中进行的一些研究在分子,生理和行为水平上将能量调节和昼夜节律钟联系起来,这增加了食物摄入时间本身可能在体重增加中发挥重要作用的可能性。本研究的重点是食物消耗的昼夜节律在体重增加中的作用。我们提供的证据表明,只在12小时的光照阶段喂食高脂肪饮食的夜间小鼠比只在12小时的黑暗阶段喂食的小鼠体重增加得更多。更好地了解昼夜节律系统对体重增加的作用可能对开发新的治疗策略以对抗当今人类面临的肥胖流行病具有重要意义。
Studies of body weight regulation have focused almost entirely on caloric intake and energy expenditure. However, a number of recent studies in animals linking energy regulation and the circadian clock at the molecular, physiological and behavioral levels raise the possibility that the timing of food intake itself may play a significant role in weight gain. The present study focused on the role of the circadian phase of food consumption in weight gain. We provide evidence that nocturnal mice fed a high fat diet only during the 12 hour light phase gain significantly more weight than mice fed only during the 12 hour dark phase. A better understanding of the role of the circadian system for weight gain could have important implications for developing new therapeutic strategies for combating the obesity epidemic facing the human population today.
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