Virtual navigation in healthy aging: Activation during learning and deactivation during retrieval predicts successful memory for spatial locations.
Virtual navigation in healthy aging: Activation during learning and deactivation during retrieval predicts successful memory for spatial locations.
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DOI：
10.1016/j.neuropsychologia.2022.108298
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发表时间：
2022-08-13
期刊：
影响因子：
2.6
通讯作者：
Zacks, Jeffrey M.
中科院分区：
文献类型：
--
作者：
Richmond, Lauren L.;Sargent, Jesse Q.;Zacks, Jeffrey M.
空间导航和空间记忆是独立生活的两项重要技能，并且已知会随着年龄的增长而受损。在这里，我们调查了健康老年人成功的空间记忆的神经相关性，以了解更多关于维持导航技能到老年的神经基础。健康的老年人观看了一个人拍摄的视频导航路线，并被要求记住物体沿着路线，然后试图记住物体的位置，虚拟地指向隐藏的物体的位置从几个位置沿着路线。在学习和指点过程中的大脑活动被功能性磁共振成像记录下来。在观看过程中颞叶和额叶区域的较大激活，以及在指向过程中上级顶叶皮层和顶内沟的较大失活，与较小的定位误差相关。这些研究结果表明，较大的诱发反应，在学习空间信息加上较大的失活的典型空间记忆区域在检索是重要的有效的空间记忆在晚年。
Spatial navigation and spatial memory are two important skills for independent living, and are known to be compromised with age. Here, we investigate the neural correlates of successful spatial memory in healthy older adults in order to learn more about the neural underpinnings of maintenance of navigation skill into old age. Healthy older adults watched a video shot by a person navigating a route and were asked to remember objects along the route, and then attempted to remember object locations by virtually pointing to the location of hidden objects from several locations along the route. Brain activity during learning and pointing was recorded with functional MRI. Larger activations in temporal and frontal regions during watching, and larger deactivations in superior parietal cortex and intraparietal sulcus during pointing, were associated with smaller location errors. These findings suggest that larger evoked responses during learning of spatial information coupled with larger deactivation of canonical spatial memory regions at retrieval are important for effective spatial memory in late life.
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