Seasonal Variations in Microtia of Chinese Population
Seasonal Variations in Microtia of Chinese Population
复制标题
中国人群小耳症的季节变化
DOI：
10.1097/scs.0000000000004790
复制
发表时间：
2018-11
影响因子：
0.9
通讯作者：
Qing-Guo Zhang
中科院分区：
文献类型：
--
作者：
Jin-Tian Hu;Qi Chen;Hui-Ying Song;Yi-Lin Cao;Yong-Biao Zhang;Xu Zhou;Tun Liu;Qing-Guo Zhang
背景：先天性出生缺陷的季节性有助于识别环境风险因素。关于小耳畸形患病率的季节性的数据很少。本文旨在确定小耳畸形的出生是否遵循一定的模式。研究方法：数据来源于2007年1月至2013年12月中国医学科学院整形外科医院第二耳再造中心收治的2669例小耳畸形患者。对照组为同期海淀区妇幼保健院产科的所有活产儿。出生月数的季节变化采用2检验进行分析。结果：共有2669例小耳畸形患者和89,273例健康存活新生儿纳入本研究。患者的出生时间高峰出现在秋季，尤其是11月，而最低点出现在春季，尤其是4月（P <0.05）。男性患者的出生时间高峰也出现在秋季，尤其是10月和11月，而低谷也出现在春季（4月）。女性患者发病的季节性不明显，高峰出现在夏秋之末，依次为8月、11月、9月，低谷出现在3月。结论：在中国本土人群中，小耳畸形患者的出生月份可能存在季节性，且存在性别差异。这种方法可能有助于研究小耳畸形的病因。
Background: Seasonality of congenital birth defect could help to identify environmental risk factors. Data concerning the seasonality of the prevalence of microtia are little. This article aims to determine whether births of microtia follow a certain pattern. Methods: Data were obtained from 2669 patients with microtia who were admitted to Second Ear Reconstruction Center of Plastic Surgery Hospital, Chinese Academy of Medical Science from January 2007 to December 2013. The controls consist of all living births from the Obstetric Department of the Haidian Maternal & Child Health Hospital during the same time. Seasonal variations in months of births were analyzed by using &khgr;2 test. Results: A total of 2669 patients with microtia and 89,273 healthy living newborns were included in this study. Birth time peak of the patients occurred in autumn, especially in November, compared with the nadir in the spring, especially in April (P G 0.05). The birth time peak of male patients occurred in autumn, too, especially in October and November, While the valley occurred in spring (April, too). However, the seasonality in female patients is not so apparent with the peak occurred in the tail of summer and autumn, especially in August, November, and September orderly, while the valley occurred in March. Conclusions: There is a possible seasonality in birth months and a difference between sexes of patients with microtia in this native Chinese population. This approach could be useful to study the etiology of microtia.
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DOI：
10.1002/tera.1420330307
发表时间：
1986-06
期刊：
Teratology
影响因子：
--
作者：
F. Fraser;M. Frecker;P. Allderdice
通讯作者：
F. Fraser;M. Frecker;P. Allderdice
影响因子：
7.7
作者：
E. Castilla;I. Orioli;R. Lugarinho;G. Dutra;J. López-Camelo;H. Campaña;Amedeo Spagnolo;P. Mastroiacovo
通讯作者：
E. Castilla;I. Orioli;R. Lugarinho;G. Dutra;J. López-Camelo;H. Campaña;Amedeo Spagnolo;P. Mastroiacovo
影响因子：
3.6
作者：
Zhang, Qing-guo;Zhang, Jiao;Shen, Hao
通讯作者：
Shen, Hao
DOI：
10.1111/j.1651-2227.1977.tb07809.x
发表时间：
1977-01
期刊：
Acta Pædiatrica
影响因子：
--
作者：
B. Sandahl
通讯作者：
B. Sandahl
影响因子：
158.5
作者：
LAMMER, EJ;CHEN, DT;SUN, SC
通讯作者：
SUN, SC