Collagen insulated from tensile damage by domains that unfold reversibly: in situ X-ray investigation of mechanical yield and damage repair in the mussel byssus.
Collagen insulated from tensile damage by domains that unfold reversibly: in situ X-ray investigation of mechanical yield and damage repair in the mussel byssus.
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通过可逆展开的域使胶原蛋白免受拉伸损伤：贻贝足丝机械屈服和损伤修复的原位 X 射线研究。
DOI：
10.1016/j.jsb.2009.03.001
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发表时间：
2009-07
影响因子：
3
通讯作者：
Waite, J. Herbert
中科院分区：
文献类型：
--
作者：
Harrington, Matthew J.;Gupta, Himadri S.;Fratzl, Peter;Waite, J. Herbert
加州贻贝（Mytilus californianus）的深海丝是高度滞后的弹性纤维，它们在波浪冲刷的岩石海岸栖息地中共同起着固着作用。在循环载荷超过机械屈服点后，螺纹表现出机械性能的损伤依赖性降低。然而，在没有活跃的细胞代谢的情况下，深渊线的远端部分能够通过时间依赖性愈合过程恢复初始材料特性。深渊线几乎完全由称为preCols的多结构域混合胶原组成，其在很大程度上决定了线的机械性质。在这里，进一步探讨了结构-性能关系，支配线程的机械性能。使用时间分辨的原位广角X射线衍射（WAXD）加上循环拉伸载荷的线程，并通过热增强损伤修复的研究过程中发生的分子重排进行了研究。结果表明，在byssal preCols的胶原结构域的机械保护的牺牲非胶原结构域的展开，在一个较慢的时间尺度上重新折叠。时间依赖性愈合主要归因于断裂的组氨酸-金属配位复合物的随机再偶联。
The byssal threads of the California mussel, Mytilus californianus, are highly hysteretic, elastomeric fibers that collectively perform a holdfast function in wave-swept rocky seashore habitats. Following cyclic loading past the mechanical yield point, threads exhibit a damage-dependent reduction in mechanical performance. However, the distal portion of the byssal thread is capable of recovering initial material properties through a time-dependent healing process in the absence of active cellular metabolism. Byssal threads are composed almost exclusively of multi-domain hybrid collagens known as preCols, which largely determine the mechanical properties of the thread. Here, the structure-property relationships that govern thread mechanical performance are further probed. The molecular rearrangements that occur during yield and damage repair were investigated using time-resolved in situ wide angle X-ray diffraction (WAXD) coupled with cyclic tensile loading of threads and through thermally enhanced damage-repair studies. Results indicate that the collagen domains in byssal preCols are mechanically protected by the unfolding of sacrificial non-collagenous domains that refold on a slower time-scale. Time-dependent healing is primarily attributed to stochastic recoupling of broken histidine-metal coordination complexes.
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影响因子：
41.2
作者：
Keckes, J;Burgert, I;Fratzl, P
通讯作者：
Fratzl, P
影响因子：
3.4
作者：
Misof, K;Rapp, G;Fratzl, P
通讯作者：
Fratzl, P
影响因子：
2.8
作者：
Rapoport, H. Scott;Shadwick, Robert E.
通讯作者：
Shadwick, Robert E.
影响因子：
5.6
作者：
GEDDES, AJ;PARKER, KD;BEIGHTON, E
通讯作者：
BEIGHTON, E
DOI：
10.1098/rstb.2001.1022
发表时间：
2002-02-28
影响因子：
6.3
作者：
Gosline, J;Lillie, M;Savage, K
通讯作者：
Savage, K