Incidence of dermatomyositis and clinically amyopathic dermatomyositis: a population-based study in Olmsted County, Minnesota.
Incidence of dermatomyositis and clinically amyopathic dermatomyositis: a population-based study in Olmsted County, Minnesota.
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DOI：
10.1001/archdermatol.2009.328
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发表时间：
2010-01
影响因子：
--
通讯作者：
Davis, Mark D. P.
中科院分区：
文献类型：
--
作者：
Bendewald, Margo J.;Wetter, David A.;Li, Xujian;Davis, Mark D. P.
旨在确定 1976 年至 2007 年明尼苏达州奥姆斯特德县新发和现有的皮肌炎及其亚型病例，并对皮肌炎和无肌病性皮肌炎的发病率和患病率进行基于人群的估计。基于人群的回顾性研究。基于社区的流行病学项目。使用罗切斯特流行病学项目，确定了诊断为皮肌炎的患者。皮肌炎和临床无肌病性皮肌炎的发病率；临床无肌病性皮肌炎的恶性肿瘤风险。在确定的 29 名患者中，其中 6 名 (21%) 患有皮肌炎临床无肌病亚型，其中 22 名 (76%) 为女性。包括所有亚型在内的皮肌炎的年龄和性别调整总发病率（95%置信区间）为每 1,000,000 人 9.63 (6.09-13.17)，临床无肌病性皮肌炎为每 1,000,000 人 2.08 (0.39-3.77)。年龄和性别调整后的患病率为每 10 万人 21.42 (13.07-29.77)。 8 名患者 (28%) 在研究期间患有恶性肿瘤；与临床无肌病性皮肌炎相比，经典皮肌炎的恶性肿瘤风险（比值比）为 4.61，但无统计学意义 (0.22-96.09) (P=.44)。皮肌炎是一种罕见疾病，临床上无肌病性皮肌炎估计占所有皮肌炎病例的 20%。需要更大规模的基于人群的研究来估计与皮肌炎亚型相关的恶性肿瘤的风险，特别是临床无肌病性皮肌炎。
To identify new and existing cases of dermatomyositis and its subtypes in Olmsted County, Minnesota, from 1976 through 2007, and to establish a population-based estimate of the incidence and prevalence of dermatomyositis and amyopathic dermatomyositis. Retrospective population-based study. Community-based epidemiology project. Using the Rochester Epidemiology Project, patients with a diagnosis of dermatomyositis were identified. Incidence of dermatomyositis and clinically amyopathic dermatomyositis; risk of malignancy in clinically amyopathic dermatomyositis. Of the 29 patients identified, 6 (21%) of these had the clinically amyopathic subtype of dermatomyositis, and 22 (76%) were female. Overall age- and sex-adjusted incidence (95% confidence interval) of dermatomyositis including all subtypes was 9.63 (6.09-13.17) per 1,000,000 and was 2.08 (0.39-3.77) per 1,000,000 for clinically amyopathic dermatomyositis. Age- and sex-adjusted prevalence was 21.42 (13.07-29.77) per 100,000. Eight patients (28%) had a malignancy during the study period; risk of malignancy (odds ratio) for classic dermatomyositis compared with clinically amyopathic dermatomyositis was 4.61 but was not statistically significant (0.22-96.09) (P=.44). Dermatomyositis is a rare disease, and clinically amyopathic dermatomyositis represents an estimated 20% of all dermatomyositis cases. Larger population-based studies are needed to estimate the risk of malignancy associated with subtypes of dermatomyositis, particularly clinically amyopathic dermatomyositis.
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DOI：
10.1016/0190-9622(91)70153-s
发表时间：
1991-06-01
影响因子：
13.8
作者：
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通讯作者：
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影响因子：
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作者：
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作者：
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通讯作者：
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影响因子：
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作者：
SIGURGEIRSSON, B;LINDELOF, B;ALLANDER, E
通讯作者：
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