Prevalence of SARS-CoV-2 Infection in Children and Their Parents in Southwest Germany.
Prevalence of SARS-CoV-2 Infection in Children and Their Parents in Southwest Germany.
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德国西南部儿童及其父母中SARS-CoV-2感染的流行情况
DOI：
10.1001/jamapediatrics.2021.0001
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发表时间：
2021-06-01
期刊：
影响因子：
26.1
通讯作者：
Kräusslich HG
中科院分区：
文献类型：
--
作者：
Tönshoff B;Müller B;Elling R;Renk H;Meissner P;Hengel H;Garbade SF;Kieser M;Jeltsch K;Grulich-Henn J;Euler J;Stich M;Chobanyan-Jürgens K;Zernickel M;Janda A;Wölfle L;Stamminger T;Iftner T;Ganzenmueller T;Schmitt C;Görne T;Laketa V;Olberg S;Plaszczyca A;Cortese M;Bartenschlager R;Pape C;Remme R;Huzly D;Panning M;Weigang S;Giese S;Ciminski K;Ankerhold J;Kochs G;Schwemmle M;Handgretinger R;Niemeyer CM;Engel C;Kern WV;Hoffmann GF;Franz AR;Henneke P;Debatin KM;Kräusslich HG
德国西南部人群样本中 1 至 10 岁儿童及其相应父母的严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 感染率和 SARS-CoV-2 抗体血清阳性率是多少？这项针对 4964 名参与者的大规模、多中心、横断面调查通过结合酶联免疫吸附测定和免疫荧光测试的结果，准确地确定了抗 SARS-CoV-2 血清阳性。估计父母中的 SARS-CoV-2 血清阳性率较低（1.8%），儿童中的血清阳性率低 3 倍（0.6%）。本研究中幼儿中 SARS-CoV-2 抗体的血清阳性率较低，可能表明它们在当前大流行期间的 SARS-CoV-2 传播中并未发挥关键作用。这项在德国西南部进行的横断面调查描述了基于人群的样本中 1 至 10 岁儿童的严重急性呼吸综合征冠状病毒 2 感染率和抗体血清阳性率，并与每个儿童的父母进行比较。基于幼儿可能在严重急性呼吸道冠状病毒 2 (SARS-CoV-2) 传播中发挥关键作用的假设，关闭学校和日托中心作为限制 2019 年新型冠状病毒病 (COVID-19) 大流行的措施。鉴于接触限制对儿童造成的严重后果，更好地了解儿童对 COVID-19 大流行的影响至关重要。在基于人群的样本中，与每个儿童的相应父母相比，描述 1 至 10 岁儿童的 SARS-CoV-2 感染率和 SARS-CoV-2 抗体血清阳性率。这项大规模、多中心、横断面调查（COVID-19 BaWü 研究）于 2020 年 4 月 22 日至 5 月 15 日期间在德国西南部招募了 1 至 10 岁的儿童以及相应的家长。可能接触 SARS-CoV-2。主要结果是 SARS-CoV-2 的感染和血清阳性率。通过逆转录聚合酶链反应检测参与者鼻咽拭子中的 SARS-CoV-2 RNA，并通过酶联免疫吸附测定和免疫荧光测试检测血清中的 SARS-CoV-2 特异性 IgG 抗体。不一致的结果通过电化学发光免疫测定、第二种酶联免疫吸附测定或基于 Luminex 的内部测定来澄清。这项研究包括 4964 名参与者：2482 名儿童（中位年龄，6 [范围，1-10] 岁；1265 名男孩 [51.0%]）和 2482 名家长（中位年龄，40 [范围，23-66] 岁；615 名男性 [24.8%]）。两名参与者 (0.04%) SARS-CoV-2 RNA 检测呈阳性。父母中估计的 SARS-CoV-2 血清阳性率较低（1.8% [95% CI, 1.2-2.4%]），儿童中的血清阳性率低 3 倍（0.6% [95% CI, 0.3-1.0%]）。在 56 个至少有 1 名子女或父母血清呈阳性的家庭中，血清呈阳性的父母与血清呈阴性的相应子女的组合比血清阴性的父母与血清呈阳性的相应子女的组合高 4.3 倍（95% CI，1.19-15.52）。我们观察到 70 份 IgG 阳性血清样本中的 66 份具有病毒中和活性（94.3%）。在这项横断面研究中，德国西南部封锁期间 1 至 10 岁儿童中 SARS-CoV-2 感染的传播特别低。因此，儿童不太可能加剧这一流行病。这项 SARS-CoV-2 流行率研究似乎是针对儿童的最大规模研究，对于临时大规模检测如何为大流行中的理性政治决策提供基础具有启发意义。
What is the rate of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections and the seroprevalence of SARS-CoV-2 antibodies in children aged 1 to 10 years and a corresponding parent in a population-based sample in southwest Germany? This large-scale, multicenter, cross-sectional investigation of 4964 participants accurately determined anti–SARS-CoV-2 seropositivity by combining the results of enzyme-linked immunosorbent assay and immunofluorescence tests. The estimated SARS-CoV-2 seroprevalence was low in parents (1.8%) and 3-fold lower in children (0.6%). The low seroprevalence of SARS-CoV-2 antibodies in young children in this study may indicate that they do not play a key role in SARS-CoV-2 spreading during the current pandemic. This cross-sectional investigation conducted in southwest Germany describes the rate of severe acute respiratory syndrome coronavirus 2 infections and the seroprevalence of antibodies in children aged 1 to 10 years, compared with a parent of each child, in a population-based sample. School and daycare closures were enforced as measures to confine the novel coronavirus disease 2019 (COVID-19) pandemic, based on the assumption that young children may play a key role in severe acute respiratory coronavirus 2 (SARS-CoV-2) spread. Given the grave consequences of contact restrictions for children, a better understanding of their contribution to the COVID-19 pandemic is of great importance. To describe the rate of SARS-CoV-2 infections and the seroprevalence of SARS-CoV-2 antibodies in children aged 1 to 10 years, compared with a corresponding parent of each child, in a population-based sample. This large-scale, multicenter, cross-sectional investigation (the COVID-19 BaWü study) enrolled children aged 1 to 10 years and a corresponding parent between April 22 and May 15, 2020, in southwest Germany. Potential exposure to SARS-CoV-2. The main outcomes were infection and seroprevalence of SARS-CoV-2. Participants were tested for SARS-CoV-2 RNA from nasopharyngeal swabs by reverse transcription–polymerase chain reaction and SARS-CoV-2 specific IgG antibodies in serum by enzyme-linked immunosorbent assays and immunofluorescence tests. Discordant results were clarified by electrochemiluminescence immunoassays, a second enzyme-linked immunosorbent assay, or an in-house Luminex-based assay. This study included 4964 participants: 2482 children (median age, 6 [range, 1-10] years; 1265 boys [51.0%]) and 2482 parents (median age, 40 [range, 23-66] years; 615 men [24.8%]). Two participants (0.04%) tested positive for SARS-CoV-2 RNA. The estimated SARS-CoV-2 seroprevalence was low in parents (1.8% [95% CI, 1.2–2.4%]) and 3-fold lower in children (0.6% [95% CI, 0.3-1.0%]). Among 56 families with at least 1 child or parent with seropositivity, the combination of a parent with seropositivity and a corresponding child with seronegativity was 4.3 (95% CI, 1.19-15.52) times higher than the combination of a parent who was seronegative and a corresponding child with seropositivity. We observed virus-neutralizing activity for 66 of 70 IgG-positive serum samples (94.3%). In this cross-sectional study, the spread of SARS-CoV-2 infection during a period of lockdown in southwest Germany was particularly low in children aged 1 to 10 years. Accordingly, it is unlikely that children have boosted the pandemic. This SARS-CoV-2 prevalence study, which appears to be the largest focusing on children, is instructive for how ad hoc mass testing provides the basis for rational political decision-making in a pandemic.
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影响因子：
56.9
作者：
Kissler, Stephen M.;Tedijanto, Christine;Lipsitch, Marc
通讯作者：
Lipsitch, Marc
影响因子：
168.9
作者：
Pollan, Marina;Perez-Gomez, Beatriz;Yotti, Raquel
通讯作者：
Yotti, Raquel
与传染病的传播相关的社会接触和混合模式。
影响因子：
15.8
作者：
Mossong, Joeel;Hens, Niel;Jit, Mark;Beutels, Philippe;Auranen, Kari;Mikolajczyk, Rafael;Massari, Marco;Salmaso, Stefania;Tomba, Gianpaolo Scalia;Wallinga, Jacco;Heijne, Janneke;Sadkowska-Todys, Malgorzata;Rosinska, Magdalena;Edmunds, W. John
通讯作者：
Edmunds, W. John
DOI：
10.1093/cid/cis307
发表时间：
2012-06
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Cowling BJ;Fang VJ;Nishiura H;Chan KH;Ng S;Ip DK;Chiu SS;Leung GM;Peiris JS
通讯作者：
Peiris JS
影响因子：
64.8
作者：
Cauchemez, Simon;Valleron, Alain-Jacques;Ferguson, Neil M.
通讯作者：
Ferguson, Neil M.