Does sex influence the incidence or severity of reperfusion-induced cardiac arrhythmias?
Does sex influence the incidence or severity of reperfusion-induced cardiac arrhythmias?
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DOI：
10.1186/s40064-015-0878-x
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Kloner RA
中科院分区：
文献类型：
--
作者：
Dow JS;Bhandari A;Hale SL;Kloner RA
在实验动物模型中，性别是否会影响心肌缺血的急性期，目前还存在争议。我们的目的是确定性别是否影响短暂冠状动脉闭塞引起的再灌注诱导心律失常的发生率或严重程度。将雄性和雌性Sprague-Dawley大鼠分配至研究。使麻醉的动物经受5分钟的冠状动脉闭塞，随后再灌注5分钟。死亡率因性别而异：10/27例（37%）男性死于VT/VF，而仅1/16例（6%）女性死于VT/VF（p = 0.033）。对17名男性和15名女性幸存者的心电图数据进行定量分析。分析显示，两组之间的室性心律失常没有其他显著差异。结论：致死性再灌注心律失常导致雄性大鼠死亡率高于雌性大鼠。在存活者中，测量的任何其他血液学参数均无差异。
Whether sex affects the acute phase of myocardial ischemia in experimental animal models is currently being debated. Our purpose was to determine if sex influences either the incidence or severity of reperfusion-induced arrhythmias resulting from a brief coronary occlusion. Male and female Sprague–Dawley rats were assigned to the study. Anesthetized animals were subjected to a 5-minute coronary artery occlusion followed by 5 minutes of reperfusion. Mortality differed by sex: 10/27 (37%) of males died due to VT/VF while only 1/16 females (6%) died due to VT/VF (p = 0.033). Quantitative analysis of the electrocardiogram was performed on data acquired from 17 male and 15 female survivors. Analysis showed no other significant differences in ventricular arrhythmias between the two groups. Conclusion: Lethal reperfusion-induced arrhythmias led to a higher mortality in male rats versus female rats. Among survivors there was no difference in any other arrhythmic parameters measured.
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影响因子：
5.5
作者：
Leblanc, N;Chartier, D;Rouleau, JL
通讯作者：
Rouleau, JL
影响因子：
6.2
作者：
Canali, Emanuele;Masci, Pier;Agati, Luciano
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DOI：
10.1177/1074248408329606
发表时间：
2009-06-01
影响因子：
2.6
作者：
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通讯作者：
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影响因子：
158.5
作者：
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通讯作者：
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影响因子：
4.5
作者：
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通讯作者：
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