Sex differences in mechanisms of cardiac excitation-contraction coupling.
Sex differences in mechanisms of cardiac excitation-contraction coupling.
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DOI：
10.1007/s00424-013-1233-0
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发表时间：
2013-05
影响因子：
4.5
通讯作者：
Howlett, Susan E.
中科院分区：
文献类型：
--
作者：
Parks, Randi J.;Howlett, Susan E.
心血管疾病的发病率和表现形式在两性之间存在差异。这并不奇怪，因为男性和女性的心脏生理学不同。临床和基础科学研究表明，心脏结构和功能存在重要的性别差异。性别差异的普遍性表明，这种差异一定是根本性的，可能在细胞水平上起作用。事实上，研究表明，与雄性动物相比，来自雌性动物的分离心室肌细胞具有较小且较慢的收缩和潜在的钙瞬变。最近的证据表明，这是由心脏兴奋-收缩偶联途径的组成部分的性别差异引起的，该途径是将肌细胞去极化与肌浆网钙释放和随后的收缩联系起来的事件序列。性激素可以在心肌细胞水平上调节细胞内钙的概念很重要，因为随着心血管疾病发病率的上升，男性和女性的这些激素水平都会下降。这篇综述着重于性别对心脏收缩的影响，特别是在细胞水平上，并强调了性别之间不同的兴奋-收缩耦合通路的特定组成部分。了解性激素对心脏钙稳态的调节可能为治疗心功能障碍和心血管疾病的治疗策略提供新的途径。
The incidence and expression of cardiovascular diseases differs between the sexes. This is not surprising, as cardiac physiology differs between men and women. Clinical and basic science investigations have shown important sex differences in cardiac structure and function. The pervasiveness of sex differences suggests that such differences must be fundamental, likely operating at a cellular level. Indeed, studies have shown that isolated ventricular myocytes from female animals have smaller and slower contractions and underlying calcium transients compared to males. Recent evidence suggests that this arises from sex differences in components of the cardiac excitation–contraction coupling pathway, the sequence of events linking myocyte depolarization to calcium release from the sarcoplasmic reticulum and subsequent contraction. The concept that sex hormones may regulate intracellular calcium at the level of the cardiomyocyte is important, as levels of these hormones decline in both men and women as the incidence of cardiovascular disease rises. This review focuses on the impact of sex on cardiac contraction, in particular at the cellular level, and highlights specific components of the excitation–contraction coupling pathway that differ between the sexes. Understanding sex hormone regulation of calcium homeostasis in the heart may reveal new avenues for therapeutic strategies to treat cardiac dysfunction and cardiovascular diseases.
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影响因子：
39.3
作者：
BUONANNO, C;ARBUSTINI, E;POPPI, A
通讯作者：
POPPI, A
DOI：
10.1152/ajpheart.00660.2005
发表时间：
2006-09-01
影响因子：
4.8
作者：
Bupha-Intr, Tepmanas;Wattanapermpool, Jonggonnee
通讯作者：
Wattanapermpool, Jonggonnee
影响因子：
3.3
作者：
Bupha-Intr, Tepmanas;Laosiripisan, Jitanan;Wattanapermpool, Jonggonnee
通讯作者：
Wattanapermpool, Jonggonnee
影响因子：
6.1
作者：
Chu, SH;Sutherland, K;Schwertz, D
通讯作者：
Schwertz, D
DOI：
10.1046/j.1440-1681.2003.03864.x
发表时间：
2003-07-01
影响因子：
2.9
作者：
Curl, CL;Wendt, IR;Kotsanas, G
通讯作者：
Kotsanas, G