HIV-associated neurocognitive disorder in HIV-infected Koreans: the Korean NeuroAIDS Project.
HIV-associated neurocognitive disorder in HIV-infected Koreans: the Korean NeuroAIDS Project.
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作者：
Ku NS;Lee Y;Ahn JY;Song JE;Kim MH;Kim SB;Jeong SJ;Hong KW;Kim E;Han SH;Song JY;Cheong HJ;Song YG;Kim WJ;Kim JM;Smith DM;Choi JY
HIV 相关神经认知障碍 (HAND) 是早期死亡的独立预测因子，并与日常生活活动中的许多困难相关。我们试图确定感染艾滋病毒的韩国人中手足口病的患病率和危险因素。此外，我们还研究了诊断 HAND 的神经心理学 (NP) 测试的筛选工具和组成部分的性能。 2012 年 3 月至 2012 年 9 月期间，连续招募了韩国首尔两家不同城市教学医院的 HIV 感染患者。参与者完成了对通常受 HIV 影响的六个认知领域的详细 NP 评估。 Frascati 标准用于诊断 HAND。还评估了四个关键问题：国际艾滋病毒痴呆量表 (IHDS) 和 MoCA-K，作为筛查 HAND 的潜在工具。在 194 名参与者中，HAND 患病率为 26.3%。无症状神经认知障碍、轻微神经认知障碍分别占HAND患者的52.9%和47.1%。在多变量分析中，血红蛋白水平≤13g/dL（p=0.046）和当前使用基于蛋白酶抑制剂的治疗方案（p=0.031）是HAND的独立危险因素。 IHDS 的敏感性和特异性分别为 72.6% 和 60.8%，MoCA-K 的敏感性和特异性分别为 52.9% 和 73.4%。 IHDS (p<0.001) 和 MoCA-K (p<0.001) 都可用于筛查 HAND。在NP测试中，凹槽钉板测试的敏感性和特异性分别为90.2%和72.0%，威斯康星卡片分类测试的敏感性和特异性分别为61.2%和84.4%。手部疾病是感染艾滋病毒的韩国人中常见的合并症。使用 IHDS、MoCA-K 和凹槽钉板测试等有用工具进行主动筛查和诊断，可用于识别这一重要的并发症。
HIV-associated neurocognitive disorder (HAND) is an independent predictor of early mortality and is associated with many difficulties in activities of daily living. We sought to determine the prevalence of and risk factors for HAND in HIV-infected Koreans. In addition, we investigated the performance of screening tools and components of neuropsychological (NP) tests for diagnosing HAND. HIV-infected patients were enrolled consecutively from two different urban teaching hospitals in Seoul, South Korea between March 2012 and September 2012. Participants completed a detailed NP assessment of six cognitive domains commonly affected by HIV. The Frascati criteria were used for diagnosing HAND. Four key questions, international HIV dementia scale (IHDS) and MoCA-K were also assessed as potential tools for screening for HAND. Among the 194 participants, the prevalence of HAND was 26.3%. Asymptomatic neurocognitive impairment, minor neurocognitive disorder accounted for 52.9% and 47.1% of the patients with HAND, respectively. In multivariate analysis, hemoglobin levels ≤13g/dL (p=0.046) and the current use of protease inhibitor-based regimen (p=0.031) were independent risk factors for HAND. The sensitivity and specificity of IHDS were 72.6% and 60.8%, and MoCA-K were 52.9% and 73.4%, respectively. IHDS (p<0.001) and MoCA-K (p<0.001) were both useful for screening for HAND. Among NP tests, the sensitivity and specificity of the Grooved Pegboard Test were 90.2% and 72.0%, and the Wisconsin Card Sorting Test were 61.2% and 84.4%, respectively. HAND is a prevalent comorbidity in HIV-infected Koreans. Active screening and diagnosis with useful tools, like IHDS, MoCA-K and Grooved Pegboard Test, could be used to identify this important complication.
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影响因子：
11.2
作者：
Ellis, RJ;Hsia, K;Dupont, R
通讯作者：
Dupont, R
DOI：
10.1017/s1355617704102130
发表时间：
2004-05-01
影响因子：
2.6
作者：
Heaton, RK;Marcotte, TD;Grant, I
通讯作者：
Grant, I
影响因子：
11.2
作者：
Letendre, SL;McCutchan, JA;Ellis, RJ
通讯作者：
Ellis, RJ
影响因子：
2.5
作者：
Bryden, PJ;Roy, EA
通讯作者：
Roy, EA
影响因子：
3.2
作者：
Cysique, Lucette A.;Brew, Bruce J.
通讯作者：
Brew, Bruce J.