Re-entrant DNA gels.
Re-entrant DNA gels.
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DOI：
10.1038/ncomms13191
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发表时间：
2016-10-21
影响因子：
16.6
通讯作者：
Sciortino, Francesco
中科院分区：
文献类型：
--
作者：
Bomboi, Francesca;Romano, Flavio;Leo, Manuela;Fernandez-Castanon, Javier;Cerbino, Roberto;Bellini, Tommaso;Bordi, Federico;Filetici, Patrizia;Sciortino, Francesco
DNA在材料开发中扮演着主要角色，通过设计自组装成复杂的超分子聚集体，这是新材料世界的基石。使用DNA纳米结构，通过密切匹配理想化的胶体颗粒模型，将复杂的理论直觉转化为实验实现，这是一条探索得少得多的途径。在这里，我们的实验表明，在多个DNA序列中的竞争相互作用encipalent的适当选择的结果成一锅DNA水凝胶，加热和冷却时熔化的成功设计。通过光散射测量的弛豫时间在有限的温度窗口中急剧减慢。相图显示了一个特殊的凹进形状，不同的键合模式之间的竞争的标志。我们的研究表明，通过将粒子形状和集体响应的物理特性编码到DNA序列中，可以合理地设计具有非常规相图和可调特性的生物相容性散装材料。形成具有非常规性质的自组装软材料可以用于许多不同的应用。在这里，Sciortino及其同事设计并实验实现了一种一锅DNA水凝胶，该水凝胶在加热和冷却时都会融化。
DNA is acquiring a primary role in material development, self-assembling by design into complex supramolecular aggregates, the building block of a new-materials world. Using DNA nanoconstructs to translate sophisticated theoretical intuitions into experimental realizations by closely matching idealized models of colloidal particles is a much less explored avenue. Here we experimentally show that an appropriate selection of competing interactions enciphered in multiple DNA sequences results into the successful design of a one-pot DNA hydrogel that melts both on heating and on cooling. The relaxation time, measured by light scattering, slows down dramatically in a limited window of temperatures. The phase diagram displays a peculiar re-entrant shape, the hallmark of the competition between different bonding patterns. Our study shows that it is possible to rationally design biocompatible bulk materials with unconventional phase diagrams and tuneable properties by encoding into DNA sequences both the particle shape and the physics of the collective response. Forming self-assembled soft materials with unconventional properties can be useful in many different applications. Here, Sciortino and co-workers have designed and experimentally realized a one-pot DNA hydrogel that melts both on heating and on cooling.
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影响因子：
41.2
作者：
Angioletti-Uberti, Stefano;Mognetti, Bortolo M.;Frenkel, Daan
通讯作者：
Frenkel, Daan
影响因子：
15
作者：
Lu, Chun-Hua;Guo, Weiwei;Willner, Itamar
通讯作者：
Willner, Itamar
影响因子：
8.6
作者：
Bianchi, Emanuela;Largo, Julio;Sciortino, Francesco
通讯作者：
Sciortino, Francesco
DOI：
10.1126/science.1227268
发表时间：
2012-11-30
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Ke Y;Ong LL;Shih WM;Yin P
通讯作者：
Yin P
影响因子：
41.2
作者：
Huebsch N;Lippens E;Lee K;Mehta M;Koshy ST;Darnell MC;Desai RM;Madl CM;Xu M;Zhao X;Chaudhuri O;Verbeke C;Kim WS;Alim K;Mammoto A;Ingber DE;Duda GN;Mooney DJ
通讯作者：
Mooney DJ