Impact of polygenic risk for coronary artery disease and cardiovascular medication burden on cognitive impairment in psychotic disorders.
Impact of polygenic risk for coronary artery disease and cardiovascular medication burden on cognitive impairment in psychotic disorders.
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冠心病多基因风险和心血管药物负担对精神病患者认知功能损害的影响
DOI：
10.1016/j.pnpbp.2021.110464
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发表时间：
2022-03-08
影响因子：
5.6
通讯作者：
Bishop JR
中科院分区：
文献类型：
--
作者：
Zhang L;Hill SK;Guo B;Wu B;Alliey-Rodriguez N;Eum S;Lizano P;Ivleva EI;Reilly JL;Keefe RSE;Keedy SK;Tamminga CA;Pearlson GD;Clementz BA;Keshavan MS;Gershon ES;Sweeney JA;Bishop JR
Cognitive impairment is a core deficit across psychotic disorders, the causes and therapeutics of which remain unclear. Epidemiological observations have suggested associations between cognitive dysfunction in psychotic disorders and cardiovascular risk factors, but an underlying etiology has not been established. Neuropsychological performance using the Brief Assessment of Cognition in Schizophrenia (BACS) was assessed in 616 individuals of European ancestry (403 psychosis, 213 controls). Polygenic risk scores for coronary artery disease (PRSCAD) were quantified for each participant across 13 p-value thresholds (PT 0.5-5e−8). Cardiovascular and psychotropic medications were categorized for association analyses. Each PRSCAD was examined in relation to the BACS and the optimized PT was confirmed with five-fold cross-validation and independent validation. Functional enrichment analyses were used to identify biological mechanisms linked to PRSCAD-cognition associations. Multiple regression analyses examined PRSCAD under the optimal PT and medication burden in relation to the BACS composite and subtest scores. Higher PRSCAD was associated with lower BACS composite scores (p=0.001) in the psychosis group, primarily driven by the Verbal Memory subtest (p<0.001). Genes linked to multiple nervous system related processes and pathways were significantly enriched in PRSCAD. After controlling for PRSCAD, a greater number of cardiovascular medications was also correlated with worse BACS performance in patients with psychotic disorders (p=0.029). Higher PRSCAD and taking more cardiovascular medications were both significantly associated with cognitive impairment in psychosis. These findings indicate that cardiovascular factors may increase the risk for cognitive dysfunction and related functional outcomes among individuals with psychotic disorders.
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影响因子：
4.5
作者：
Eum S;Hill SK;Rubin LH;Carnahan RM;Reilly JL;Ivleva EI;Keedy SK;Tamminga CA;Pearlson GD;Clementz BA;Gershon ES;Keshavan MS;Keefe RSE;Sweeney JA;Bishop JR
通讯作者：
Bishop JR
DOI：
10.1176/appi.ajp.2015.14091200
发表时间：
2016-04-01
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Clementz BA;Sweeney JA;Hamm JP;Ivleva EI;Ethridge LE;Pearlson GD;Keshavan MS;Tamminga CA
通讯作者：
Tamminga CA
影响因子：
1.7
作者：
Foguet-Boreu, Quinti;Guardia Sancho, Anna;Munoz Prados, Jordina
通讯作者：
Munoz Prados, Jordina
影响因子：
30.8
作者：
Bulik-Sullivan, Brendan K.;Loh, Po-Ru;Finucane, Hilary K.;Ripke, Stephan;Yang, Jian;Patterson, Nick;Daly, Mark J.;Price, Alkes L.;Neale, Benjamin M.
通讯作者：
Neale, Benjamin M.
影响因子：
8.3
作者：
De Hert M;Detraux J;Vancampfort D
通讯作者：
Vancampfort D