Keratin 8 expression in head and neck epithelia.
Keratin 8 expression in head and neck epithelia.
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DOI：
10.1186/1471-2407-8-267
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发表时间：
2008-09-22
期刊：
影响因子：
3.8
通讯作者：
Gires O
中科院分区：
文献类型：
--
作者：
Matthias C;Mack B;Berghaus A;Gires O
The intermediate filament forming protein keratin 8 (K8) is a tumour-associated antigen, which was shown to be over-expressed in a variety of malignancies. Here, we present a study of K8 expression in squamous epithelia of the head and neck area, including normal mucosa, hyperplastic and dysplastic leukoplakia, carcinomas of different sub-localisations, and lymph node metastases. K8 expression was assessed upon immunohistochemistry with specific antibodies in cryosections of primary tumours of the head and neck area. K8 expression was characteristic of transformed tissue and marked early stages of disease, i.e. dysplastic oral leukoplakia, but not normal or hyperplastic epithelium. With the exception of carcinomas of the larynx and the tongue, K8 expression also strictly differentiated carcinomas from normal epithelium of the same origin. Furthermore, K8high was characteristic of cells, which had detached from the sites of primary tumours and had been invading the surrounding tissue at the time point of surgery. K8 is an excellent marker for head and neck malignancies, which allows for early detection as well as for visualisation of potentially disseminating tumour cells in vivo.
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影响因子：
4.8
作者：
Hembrough, TA;Li, L;Gonias, SL
通讯作者：
Gonias, SL
影响因子：
10.3
作者：
Lacina, L.;Smetana, K., Jr.;Andre, S.
通讯作者：
Andre, S.
DOI：
10.1073/pnas.90.9.4261
发表时间：
1993-05-01
影响因子：
11.1
作者：
CHU, YW;RUNYAN, RB;HENDRIX, MJC
通讯作者：
HENDRIX, MJC
DOI：
10.1083/jcb.117.3.583
发表时间：
1992-05
期刊：
The Journal of cell biology
影响因子：
--
作者：
Omary MB;Baxter GT;Chou CF;Riopel CL;Lin WY;Strulovici B
通讯作者：
Strulovici B
DOI：
10.1083/jcb.200602146
发表时间：
2006-07-03
期刊：
The Journal of cell biology
影响因子：
--
作者：
Ku NO;Omary MB
通讯作者：
Omary MB