Concise Synthesis of Functionalized Benzocyclobutenones.
Concise Synthesis of Functionalized Benzocyclobutenones.
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DOI：
10.1016/j.tet.2014.03.080
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发表时间：
2014-07-08
期刊：
影响因子：
2.1
通讯作者：
Dong, Guangbin
中科院分区：
文献类型：
--
作者：
Chen, P. -H.;Savage, Nikolas A.;Dong, Guangbin
A concise approach to access functionalized benzocyclobutenones from 3-halophenol derivatives is described. This modified synthesis employs a [2+2] cycloaddition between benzynes generated from dehydrohalogenation of aryl halides using LiTMP and acetaldehyde enolate generated from n-BuLi and THF, followed by oxidation of the benzocyclobutenol intermediates to provide benzocyclobutenones. The [2+2] reaction can be run on a 10-gram scale with an increased yield. A number of functional groups including alkenes and alkynes are tolerated. Coupling of benzynes with ketene silyl acetals to give 8-substituted benzocyclobutenones is also demonstrated.
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影响因子：
15
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1139/v95-205
发表时间：
1995-10-01
期刊：
CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE
影响因子：
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通讯作者：
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影响因子：
4.3
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影响因子：
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通讯作者：
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