DIANA-microT Web server upgrade supports Fly and Worm miRNA target prediction and bibliographic miRNA to disease association.
DIANA-microT Web server upgrade supports Fly and Worm miRNA target prediction and bibliographic miRNA to disease association.
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DOI：
10.1093/nar/gkr294
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发表时间：
2011-07
影响因子：
14.9
通讯作者：
Hatzigeorgiou AG
中科院分区：
文献类型：
--
作者：
Maragkakis M;Vergoulis T;Alexiou P;Reczko M;Plomaritou K;Gousis M;Kourtis K;Koziris N;Dalamagas T;Hatzigeorgiou AG
microRNA（miRNAs）是一类内源性小分子RNA，通过转录后调节基因表达参与多种生物学过程。DIANA-microT Web服务器提供了一个用户友好的界面，用于对人类和小鼠中的miRNA靶标进行全面的计算分析。该服务器现在已经扩展到支持两个广泛研究的物种的预测：黑腹果蝇和秀丽隐杆线虫。在更新的版本中，Web服务器通过书目分析使miRNAs与疾病的关联成为可能，并为miRNAs在生物过程中的潜在参与提供了见解。用于描述成熟miRNA沿着不同miRBase版本的命名法已经被广泛分析，并且已经提取了每个miRNA的命名历史。这使得能够识别miRNA出版物，而不管可能的命名变化。用户交互已得到进一步改进，允许用户保存他们希望进一步分析的结果。现在提供了与UCSC基因组浏览器的连接，使用户能够轻松地预览预测的结合位点，与广泛的基因组轨迹（如单核苷酸多态性）进行比较。Web服务器可在www.microrna.gr/microT-v4上公开访问。
microRNAs (miRNAs) are small endogenous RNA molecules that are implicated in many biological processes through post-transcriptional regulation of gene expression. The DIANA-microT Web server provides a user-friendly interface for comprehensive computational analysis of miRNA targets in human and mouse. The server has now been extended to support predictions for two widely studied species: Drosophila melanogaster and Caenorhabditis elegans. In the updated version, the Web server enables the association of miRNAs to diseases through bibliographic analysis and provides insights for the potential involvement of miRNAs in biological processes. The nomenclature used to describe mature miRNAs along different miRBase versions has been extensively analyzed, and the naming history of each miRNA has been extracted. This enables the identification of miRNA publications regardless of possible nomenclature changes. User interaction has been further refined allowing users to save results that they wish to analyze further. A connection to the UCSC genome browser is now provided, enabling users to easily preview predicted binding sites in comparison to a wide array of genomic tracks, such as single nucleotide polymorphisms. The Web server is publicly accessible in www.microrna.gr/microT-v4.
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影响因子：
5.7
作者：
Hiroki, Eri;Akahira, Jun-ichi;Yaegashi, Nobuo
通讯作者：
Yaegashi, Nobuo
影响因子：
64.5
作者：
LEE, RC;FEINBAUM, RL;AMBROS, V
通讯作者：
AMBROS, V
影响因子：
10.5
作者：
Kiriakidou, M;Nelson, PT;Hatzigeorgiou, A
通讯作者：
Hatzigeorgiou, A
影响因子：
7
作者：
Friedman, Robin C.;Farh, Kyle Kai-How;Bartel, David P.
通讯作者：
Bartel, David P.
影响因子：
9.2
作者：
Lall, S;Grün, D;Rajewsky, N
通讯作者：
Rajewsky, N