Remote Loading of Gas Bubbles into Polylactic Acid Microcapsules Creates Acoustically Active Janus Particles.

Remote Loading of Gas Bubbles into Polylactic Acid Microcapsules Creates Acoustically Active Janus Particles.
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DOI:
10.1021/acsapm.1c01562
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发表时间:
2022-02-11
影响因子:
5
通讯作者:
Sirsi SR
Sirsi SR
中科院分区:
化学2区
文献类型:
--
作者:
Honari A;Kapilavaih PS;Akter N;Sirsi SR

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聚合物微胶囊 (MC) 是用于药物输送和体内成像等生物医学应用的生物相容剂。我们发现了一种将空气远程加载到具有水性核的聚乳酸 (PLA) 基 MC 中的方法。当微胶囊悬浮在高含量甘油和丙二醇溶液中时,气体溶解度的变化导致气泡通过“茴香酒样”效应在核心内成核。由此产生的气泡取代了 MC 的内部液体,但小分子保留在其内部。残留含量分布不均匀;相反,它定位于一个特定位置,产生充满气体的两面神粒子。
Polymeric microcapsules (MCs) are biocompatible agents used in biomedical applications such as drug delivery and in vivo imaging. We have discovered a method of remotely loading air into polylactic acid (PLA)-based MCs with an aqueous core. When the microcapsules are suspended in high content glycerol and propylene glycol solutions, changes in gas solubility cause bubbles to nucleate within the core through an “Ouzo-like” effect. The resulting bubble displaces the internal fluid of the MCs, but small molecules are retained in their interior. The residual content does not homogeneously distribute; rather, it localizes to one specific location, creating gas-filled Janus particles.
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