Beta-adrenergic agonists inhibit corticosteroid-induced apoptosis of airway epithelial cells.
Beta-adrenergic agonists inhibit corticosteroid-induced apoptosis of airway epithelial cells.
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β-肾上腺素能激动剂抑制皮质类固醇诱导的气道上皮细胞凋亡。
DOI：
10.1152/ajplung.00030.2003
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
White,StevenR
中科院分区：
文献类型：
--
作者：
Tse,Roberta;Marroquin,BerthaA;Dorscheid,DelbertR;White,StevenR
Airway epithelial damage is a feature of persistent asthma. Treatment with inhaled and oral corticosteroids may suppress inflammation and gain clinical control despite continued epithelial damage. We have previously demonstrated that corticosteroids elicit apoptosis of airway epithelial cells in culture. β-Adrenergic receptor agonists are commonly used in asthma therapy and can inhibit corticosteroid-induced apoptosis of eosinophils. We tested the hypothesis that β-adrenergic agonists would inhibit corticosteroid-induced airway epithelial cell apoptosis in cultured primary airway epithelial cells and in the cell line 1HAEo-. Albuterol treatment inhibited dexamethasone-induced apoptosis completely but did not inhibit apoptosis induced by Fas receptor activation. The protective effect of albuterol was duplicated by two different analogs of protein kinase A. The protective effect was not associated with increased translocation of the glucocorticoid receptor to the nucleus nor with changes in glucocorticoid receptor-mediated transcriptional activation or repression. We demonstrate that β-adrenergic agonists can inhibit corticosteroid-induced apoptosis but not apoptosis induced by Fas activation. These data suggest that one potential deleterious effect of corticosteroid therapy in asthma can be prevented by concomitant β-adrenergic agonist treatment.
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影响因子：
64.8
作者：
P. Jacobs;C. M. Wilson;J. A. Sprenkle;N. Rosenshein;B. Migeon
通讯作者：
B. Migeon
人绒毛膜促性腺激素β亚基上的单克隆抗体识别的拓扑抗原决定簇。
DOI：
--
发表时间：
1987
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Bidart,JM;Troalen,F;Salesse,R;Bousfield,GR;Bohuon,CJ;Bellet,DH
通讯作者：
Bellet,DH
人绒毛膜促性腺激素α亚基的抗原决定簇。
DOI：
--
发表时间：
1988
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Bidart,JM;Troalen,F;Bousfield,GR;Birken,S;Bellet,DH
通讯作者：
Bellet,DH
绒毛膜绒毛取样：1000例产科经验分析
影响因子：
3
作者：
B. Brambati;A. Oldrini;E. Ferrazzi;A. Lanzani
通讯作者：
A. Lanzani
影响因子：
9.8
作者：
A. E. Szulman;U. Surti
通讯作者：
U. Surti