Damage-associated molecular patterns in cancer: a double-edged sword.
Damage-associated molecular patterns in cancer: a double-edged sword.
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损伤相关分子模式 (DAMP) 是为了响应细胞死亡和应激而释放的，是无菌炎症的有效触发因素。最近的证据表明，DAMP 也可能在癌症的发展以及宿主对细胞毒性抗肿瘤治疗的反应中发挥关键作用。因此，DAMP 可以通过警告免疫系统死亡肿瘤细胞的存在来发挥保护功能，从而触发免疫原性肿瘤细胞死亡。另一方面，细胞死亡和DAMPs的释放也可能引发慢性炎症，从而促进肿瘤的发生或进展。在这里，我们将回顾候选DAMP及其受体的贡献，并讨论DAMP作为肿瘤促进和抗肿瘤效应物的证据，以及未解决的问题，例如非肿瘤细胞释放DAMP以及肿瘤特异性DAMP的存在。
Damage-associated molecular patterns (DAMPs) are released in response to cell death and stress, and are potent triggers of sterile inflammation. Recent evidence suggests that DAMPs may also have a key role in the development of cancer as well as in the host response to cytotoxic anti-tumor therapy. As such, DAMPs may exert protective functions by alerting the immune system to the presence of dying tumor cells, thereby triggering immunogenic tumor cell death. On the other hand, cell death and release of DAMPs may also trigger chronic inflammation and thereby promote the development or progression of tumors. Here, we will review the contribution of candidate DAMPs and their receptors and discuss the evidence for DAMPs as tumor-promoting and anti-tumor effectors as well as unsolved questions such as DAMP release from non-tumor cells as well as the existence of tumor-specific DAMPs.
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